Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HK1 | P19367 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GALK1 | P51570 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9313816 | 0.79 | ALDH1A1 (0.53) | TSHRBRD4CREBBPMAPTNPC1 | |
| SCHEMBL11141197 | 0.79 | PNMT (0.42) | PNMTGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29407071 | 0.73 | HTR2A (0.49) | TSHRPNMTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL21693355 | 0.73 | TSHR (0.54) | TSHRBRD4CREBBPMAPTNPC1 | |
| SCHEMBL28061343 | 0.73 | TSHR (0.54) | TSHRBRD4CREBBPMAPTNPC1 | |
| SCHEMBL28529344 | 0.73 | HTR2A (0.49) | TSHRPNMTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL25758208 | 0.71 | HTR2C (0.33) | PNMTMEN1KMT2AGAAHTR5A | |
| SCHEMBL14313350 | 0.70 | TSHR (0.51) | TSHRBRD4CREBBPMAPTNPC1 | |
| SCHEMBL17075216 | 0.68 | AR (0.42) | MEN1KMT2AALDH1A1GAA | |
| SCHEMBL6333376 | 0.68 | GAA (0.43) | TSHRMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0108715-A1 | Dibenzazepine carboxamides | CIBA-GEIGY AG (CH) | 1984-05-16 | — | — | EP | disclosed |