SCHEMBL28529344

SCHEMBL28529344

FC(F)(F)C1Cc2ccccc2-c2ccccc21

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.49
NOS3 P29474 3/20 0.38
NOS2 P35228 3/20 0.38
PNMT P11086 1/20 0.38
ACHE P22303 1/20 0.36
TSHR P16473 1/20 0.33
HTR1A P08908 1/20 0.33
DRD2 P14416 1/20 0.33
CDK8 P49336 1/20 0.33
CDK5 Q00535 1/20 0.33
CHRNA7 P36544 1/20 0.33
GRIN2D O15399 1/20 0.32
GRIN3B O60391 1/20 0.32
GRIN1 Q05586 1/20 0.32
GRIN2A Q12879 1/20 0.32
GRIN2B Q13224 1/20 0.32
GRIN2C Q14957 1/20 0.32
GRIN3A Q8TCU5 1/20 0.32
GPR3 P46089 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29407071 1.00 HTR2A (0.49) HTR2ANOS3NOS2PNMTACHE
SCHEMBL11141197 0.84 PNMT (0.42) HTR2APNMTGRIN2DGRIN3BGRIN1
SCHEMBL29407534 0.82 PDK2 (0.38) HTR2ANOS3NOS2ACHEHTR1A
SCHEMBL28523441 0.82 PDK2 (0.38) HTR2ANOS3NOS2ACHEHTR1A
SCHEMBL29407087 0.78 DRD1 (0.46) HTR2AACHETSHRDRD2
SCHEMBL28528151 0.78 DRD1 (0.46) HTR2AACHETSHRDRD2
SCHEMBL11523523 0.77 ACHE (0.53) PNMTACHETSHR
SCHEMBL7560591 0.74 HTR2A (0.53) HTR2ANOS3NOS2ACHETSHR
SCHEMBL11117413 0.73 TSHR (0.50) PNMTTSHRGRIN2DGRIN3BGRIN1
SCHEMBL14870745 0.71 HTR2A (0.55) HTR2ANOS3NOS2ACHETSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112441875-B Method for copper photocatalytic synthesis of 9-trifluoromethyl-9, 10-dihydrophenanthrene compound 浙江工业大学 2022-03-18 CN claimed
CN-112441874-B Method for synthesizing 9-trifluoromethyl-9, 10-dihydrophenanthrene compound by virtue of iridium photocatalysis 浙江工业大学 2022-03-18 CN claimed
CN-112441874-A Method for synthesizing 9-trifluoromethyl-9, 10-dihydrophenanthrene compound by virtue of iridium photocatalysis 浙江工业大学 2021-03-05 CN claimed
CN-112441875-A Method for copper photocatalytic synthesis of 9-trifluoromethyl-9, 10-dihydrophenanthrene compound 浙江工业大学 2021-03-05 CN claimed
CN-112441875-B Method for copper photocatalytic synthesis of 9-trifluoromethyl-9, 10-dihydrophenanthrene compound 浙江工业大学 2022-03-18 CN disclosed
CN-112441875-B Method for copper photocatalytic synthesis of 9-trifluoromethyl-9, 10-dihydrophenanthrene compound 浙江工业大学 2022-03-18 CN disclosed
CN-112441875-B Method for copper photocatalytic synthesis of 9-trifluoromethyl-9, 10-dihydrophenanthrene compound 浙江工业大学 2022-03-18 CN disclosed
CN-112441874-B Method for synthesizing 9-trifluoromethyl-9, 10-dihydrophenanthrene compound by virtue of iridium photocatalysis 浙江工业大学 2022-03-18 CN disclosed
CN-112441874-B Method for synthesizing 9-trifluoromethyl-9, 10-dihydrophenanthrene compound by virtue of iridium photocatalysis 浙江工业大学 2022-03-18 CN disclosed
CN-112441874-B Method for synthesizing 9-trifluoromethyl-9, 10-dihydrophenanthrene compound by virtue of iridium photocatalysis 浙江工业大学 2022-03-18 CN disclosed
CN-112441874-A Method for synthesizing 9-trifluoromethyl-9, 10-dihydrophenanthrene compound by virtue of iridium photocatalysis 浙江工业大学 2021-03-05 CN disclosed
CN-112441874-A Method for synthesizing 9-trifluoromethyl-9, 10-dihydrophenanthrene compound by virtue of iridium photocatalysis 浙江工业大学 2021-03-05 CN disclosed
CN-112441874-A Method for synthesizing 9-trifluoromethyl-9, 10-dihydrophenanthrene compound by virtue of iridium photocatalysis 浙江工业大学 2021-03-05 CN disclosed
CN-112441875-A Method for copper photocatalytic synthesis of 9-trifluoromethyl-9, 10-dihydrophenanthrene compound 浙江工业大学 2021-03-05 CN disclosed
CN-112441875-A Method for copper photocatalytic synthesis of 9-trifluoromethyl-9, 10-dihydrophenanthrene compound 浙江工业大学 2021-03-05 CN disclosed
CN-112441875-A Method for copper photocatalytic synthesis of 9-trifluoromethyl-9, 10-dihydrophenanthrene compound 浙江工业大学 2021-03-05 CN disclosed