Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 8/20 | 0.57 |
| ▸ | BCL2 | P10415 | 5/20 | 0.48 |
| ▸ | BAK1 | Q16611 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL588394 | 0.84 | SIGMAR1 (0.67) | HTR7BCL2BAK1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL587708 | 0.83 | SIGMAR1 (0.65) | HTR7BCL2BAK1KDM4EALDH1A1 | |
| SCHEMBL2194377 | 0.83 | HTR7 (0.63) | HTR7BCL2BAK1KDM4EALDH1A1 | |
| SCHEMBL1138135 | 0.83 | HTR7 (0.60) | HTR7BCL2BAK1KDM4EALDH1A1 | |
| SCHEMBL376781 | 0.83 | HTR7 (0.56) | HTR7BCL2BAK1KDM4EALDH1A1 | |
| SCHEMBL1111682 | 0.83 | HTR7 (0.56) | HTR7BCL2BAK1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9859525 | 0.82 | HTR7 (0.62) | HTR7BCL2BAK1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5689236 | 0.82 | HTR7 (0.55) | HTR7BCL2BAK1KDM4EALDH1A1 | |
| SCHEMBL3988740 | 0.82 | HTR7 (0.58) | HTR7BCL2BAK1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL30688262 | 0.82 | HTR7 (0.55) | HTR7BCL2BAK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102105449-A | Arylsulfonamide compounds, compositions and methods of use | GENENTECH INC | 2011-06-22 | — | — | CN | disclosed |
| US-20110098305-A1 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | BAELL JONATHAN BAYLDON | 2011-04-28 | — | — | US | disclosed |
| EP-2279174-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009143246-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098305-A1 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | BAX, API5, BCL2 | HTR7 2134/4885BCL2 3/4885BAK1 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.