Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1982985 | 0.77 | CYP3A4 (0.47) | — | |
| SCHEMBL28575817 | 0.75 | MAPT (0.40) | EGFR | |
| SCHEMBL30949930 | 0.75 | MAPT (0.40) | EGFR | |
| SCHEMBL1808544 | 0.74 | EGFR (0.38) | EGFRTDO2 | |
| SCHEMBL30961886 | 0.74 | EGFR (0.38) | EGFRTDO2 | |
| SCHEMBL2811653 | 0.73 | PKM (0.31) | — | |
| SCHEMBL6903705 | 0.73 | HPGD (0.54) | TDO2 | |
| SCHEMBL1287815 | 0.73 | MCL1 (0.46) | — | |
| SCHEMBL9037556 | 0.72 | — | — | |
| SCHEMBL25278009 | 0.71 | KDM4E (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4455312-A | 2-(o-Carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 and derivatives thereof, and application as antiphlogistics | KIEVSKY NAUCHNO-ISSLEDOVATELSKY INSTITUT FARMAKOLOGIII TOXIKOLOGII USSR. KIEV ULITSA EXHENA POTIE, 14 | 1984-06-19 | — | — | US | disclosed |