Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11106121 | 0.79 | PDE3B (0.66) | PDE3BPDE3AADORA1KDM4EHPGD | |
| SCHEMBL11100684 | 0.73 | BRD4 (0.42) | PDE3BPDE3ABRD4GAA | |
| SCHEMBL11109509 | 0.72 | ALDH1A1 (0.53) | ALDH1A1KDM4EBRD4L3MBTL1GAA | |
| SCHEMBL10756489 | 0.69 | PDE3B (0.55) | PDE3BPDE3A | |
| SCHEMBL10762086 | 0.69 | PDE4B (0.52) | PDE3BPDE3AALDH1A1GAA | |
| SCHEMBL11236017 | 0.68 | MAPK1 (0.49) | PDE3BPDE3ABRD4CDK5CDK5R1 | |
| SCHEMBL11238599 | 0.68 | PDE3B (0.49) | PDE3BPDE3ABRD4 | |
| SCHEMBL11118932 | 0.66 | PDE3B (0.57) | PDE3BPDE3AKDM4EHPGDBRD4 | |
| SCHEMBL11241422 | 0.65 | PDE3B (0.43) | PDE3BPDE3AALDH1A1BRD4TYMS | |
| SCHEMBL11223772 | 0.65 | PDE3A (0.73) | PDE3BPDE3AALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109628-A1 | 2(1H)-pyridinones and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1984-05-30 | — | — | EP | disclosed |