Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.52 |
| ▸ | PDE4A | P27815 | 9/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.52 |
| ▸ | ADH5 | P11766 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 3/20 | 0.38 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10761253 | 0.85 | PDE3A (0.49) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| Hydrochloric Acid SCHEMBL10758308 | 0.84 | PDE3A (0.48) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL10756489 | 0.79 | PDE3B (0.55) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL11106121 | 0.76 | PDE3B (0.66) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL30305324 | 0.71 | ADH5 (0.66) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL10763565 | 0.70 | PDE3B (0.53) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL11117888 | 0.69 | PDE3B (0.43) | PDE3BPDE3AALDH1A1GAA | |
| SCHEMBL7343758 | 0.69 | PDE3B (0.51) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL30558759 | 0.69 | ALDH1A1 (0.71) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL300802 | 0.68 | CYP3A4 (0.61) | PDE4BPDE4APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4699914-A | CONGESTIVE HEART FAILURE | A. NATTERMANN & CIE GMBH (DE) | 1987-10-13 | — | — | US | disclosed |