SCHEMBL11118988

SCHEMBL11118988

O=C(/C=C\c1ccc(N(c2ccccc2)c2ccccc2)cc1)/C=C/c1ccc(N(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.67
F3 P13726 3/20 0.67
CYP2D6 P10635 2/20 0.67
CYP2C9 P11712 2/20 0.67
MAPT P10636 2/20 0.67
SMN1; SMN2 Q16637 2/20 0.67
PLIN1 O60240 1/20 0.67
ALDH1A1 P00352 1/20 0.67
LMNA P02545 1/20 0.67
RECQL P46063 1/20 0.67
PLIN5 Q00G26 1/20 0.67
ABHD5 Q8WTS1 1/20 0.67
HSD17B3 P37058 1/20 0.61
TRPM8 Q7Z2W7 4/20 0.55
HSD11B1 P28845 2/20 0.53
TYR P14679 1/20 0.53
HDAC3 O15379 1/20 0.50
TNKS O95271 1/20 0.50
HDAC4 P56524 1/20 0.50
HDAC1 Q13547 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11118989 1.00 CYP1A2 (0.67) CYP1A2F3CYP2D6CYP2C9MAPT
SCHEMBL16789346 0.90 GSK3B (0.62) CYP1A2F3CYP2D6CYP2C9MAPT
SCHEMBL380761 0.89 HCAR2 (0.67) CYP1A2F3CYP2D6CYP2C9MAPT
SCHEMBL16353241 0.89 HCAR2 (0.67) CYP1A2F3CYP2D6CYP2C9MAPT
SCHEMBL380760 0.89 HCAR2 (0.67) CYP1A2F3CYP2D6CYP2C9MAPT
SCHEMBL16353264 0.87 HCAR2 (0.64) CYP1A2F3CYP2D6CYP2C9MAPT
SCHEMBL16353257 0.87 HCAR2 (0.64) CYP1A2F3CYP2D6CYP2C9MAPT
SCHEMBL23866731 0.85 HAO1 (0.61) MAPTALDH1A1TRPM8HDAC3HDAC4
SCHEMBL382021 0.85 TRPM8 (0.51) CYP1A2F3CYP2D6CYP2C9MAPT
SCHEMBL382022 0.85 TRPM8 (0.51) CYP1A2F3CYP2D6CYP2C9MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0011980-B1 PHOTOCONDUCTIVE LAYERS CONTAINING A MIXTURE OF AT LEAST TWO DIFFERENT ORGANIC PHOTOCONDUCTORS AND ELECTROPHOTOGRAPHIC ELEMENTS COMPRISING SAID LAYERS EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1984-03-28 EP disclosed
EP-0011980-A1 Photoconductive layers containing a mixture of at least two different organic photoconductors and electrophotographic elements comprising said layers EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1980-06-11 EP disclosed