SCHEMBL382022

SCHEMBL382022

O=C(Cl)C=Cc1ccc(N(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 7/20 0.51
MAPT P10636 3/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
HDAC3 O15379 2/20 0.47
HDAC4 P56524 2/20 0.47
HDAC1 Q13547 2/20 0.47
HDAC2 Q92769 2/20 0.47
HDAC8 Q9BY41 2/20 0.47
HDAC6 Q9UBN7 2/20 0.47
PLIN1 O60240 2/20 0.47
LMNA P02545 2/20 0.47
RECQL P46063 2/20 0.47
PLIN5 Q00G26 2/20 0.47
ABHD5 Q8WTS1 2/20 0.47
TNKS O95271 1/20 0.47
HCAR2 Q8TDS4 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
TNKS2 Q9H2K2 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL382021 1.00 TRPM8 (0.51) TRPM8MAPTSMN1; SMN2HDAC3HDAC4
SCHEMBL380760 0.85 HCAR2 (0.67) TRPM8MAPTSMN1; SMN2HDAC3HDAC4
SCHEMBL16353241 0.85 HCAR2 (0.67) TRPM8MAPTSMN1; SMN2HDAC3HDAC4
SCHEMBL380761 0.85 HCAR2 (0.67) TRPM8MAPTSMN1; SMN2HDAC3HDAC4
SCHEMBL11118989 0.85 CYP1A2 (0.67) TRPM8MAPTSMN1; SMN2HDAC3HDAC4
SCHEMBL11118988 0.85 CYP1A2 (0.67) TRPM8MAPTSMN1; SMN2HDAC3HDAC4
SCHEMBL16353264 0.84 HCAR2 (0.64) TRPM8MAPTSMN1; SMN2HDAC3HDAC4
SCHEMBL16353257 0.84 HCAR2 (0.64) TRPM8MAPTSMN1; SMN2HDAC3HDAC4
SCHEMBL37936 0.82 MAPT (0.67) TRPM8MAPTSMN1; SMN2HDAC3HDAC4
SCHEMBL37935 0.82 MAPT (0.67) TRPM8MAPTSMN1; SMN2HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2261299-B1 AROMATIC AMINE COMPOSITIONS AND ELECTRONIC DEVICES MADE WITH SUCH COMPOSITIONS DU PONT (US) 2016-01-06 EP disclosed
US-8716697-B2 Electronic devices made with crosslinkable compounds and copolymers E I DU PONT DE NEMOURS AND COMPANY (US) 2014-05-06 US disclosed
EP-1723214-B1 AROMATIC AMINE COMPOSITIONS COMPRISING AND ELECTRONIC DEVICES MADE WITH SUCH COMPOSITIONS DU PONT (US) 2012-01-25 EP disclosed
EP-2261299-A2 Aromatic amine compositions and electronic devices made with such compositions E. I. du Pont de Nemours and Company (US) 2010-12-15 EP disclosed
US-20080132622-A1 ELECTRONIC DEVICES MADE WITH CROSSLINKABLE COMPOUNDS AND COPOLYMERS E. I. DU PONT DE NEMOURS AND COMPANY 2008-06-05 US disclosed
US-7365230-B2 Cross-linkable polymers and electronic devices made with such polymers E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-04-29 US disclosed
EP-1723214-A1 AROMATIC AMINE COMPOSITIONS COMPRISING AND ELECTRONIC DEVICES MADE WITH SUCH COMPOSITIONS E.I.Du pont de nemours and company (US) 2006-11-22 EP disclosed
WO-2005083034-A1 AROMATIC AMINE COMPOSITIONS COMPRISING AND ELECTRONIC DEVICES MADE WITH SUCH COMPOSITIONS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2005-09-09 WO disclosed
US-20050184287-A1 Cross-linkable polymers and electronic devices made with such polymers LG CHEM, LTD. (KR) 2005-08-25 US disclosed
US-5080989-A Polycarbonate, solvent resistance EASTMAN KODAK COMPANY (US) 1992-01-14 US disclosed
US-4322487-A Composite electrically photosensitive particles for electrophoretic migration imaging process EASTMAN KODAK COMPANY (US) 1982-03-30 US disclosed
US-4018606-A Organic azo pigment sensitizers for photoconductive layers EASTMAN KODAK COMPANY (US) 1977-04-19 US disclosed
US-4018607-A Crystalline organic pigment sensitizers for photoconductive layers EASTMAN KODAK COMPANY (US) 1977-04-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080132622-A1 ELECTRONIC DEVICES MADE WITH CROSSLINKABLE COMPOUNDS AND COPOLYMERS GJB2, ERCC1, GJA1 TRPM8 1341/4885MAPT 924/4885SMN1; SMN2 2023/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.