SCHEMBL380760

SCHEMBL380760

O=C(O)/C=C/c1ccc(N(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 2/20 0.67
HDAC3 O15379 2/20 0.67
HDAC4 P56524 2/20 0.67
HDAC1 Q13547 2/20 0.67
HDAC7 Q8WUI4 2/20 0.67
HDAC2 Q92769 2/20 0.67
HDAC10 Q969S8 2/20 0.67
HDAC11 Q96DB2 2/20 0.67
HDAC8 Q9BY41 2/20 0.67
HDAC6 Q9UBN7 2/20 0.67
HDAC9 Q9UKV0 2/20 0.67
HDAC5 Q9UQL6 2/20 0.67
TNKS O95271 1/20 0.67
TNKS2 Q9H2K2 1/20 0.67
FFAR1 O14842 1/20 0.58
ESR1 P03372 2/20 0.57
ESR2 Q92731 2/20 0.57
CA12 O43570 2/20 0.57
AKR1B10 O60218 2/20 0.57
CA1 P00915 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL380761 1.00 HCAR2 (0.67) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL16353241 1.00 HCAR2 (0.67) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL16353264 0.98 HCAR2 (0.64) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL16353257 0.98 HCAR2 (0.64) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL13326884 0.91 HDAC2 (0.60) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL16353247 0.90 TRPM8 (0.63) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL11118988 0.89 CYP1A2 (0.67) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL11118989 0.89 CYP1A2 (0.67) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL17321127 0.87 TRPM8 (0.60) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL17321095 0.85 HCAR2 (0.53) HCAR2HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9541848-B2 Electrophotographic photoreceptor Konica Minolta, Inc. (JP) 2017-01-10 US disclosed
US-9541848-B2 Electrophotographic photoreceptor Konica Minolta, Inc. (JP) 2017-01-10 US disclosed
US-9304417-B2 Electrophotographic photoreceptor, electrophotographic image forming apparatus and process cartridge Konica Minolta, Inc. (JP) 2016-04-05 US disclosed
US-9304417-B2 Electrophotographic photoreceptor, electrophotographic image forming apparatus and process cartridge Konica Minolta, Inc. (JP) 2016-04-05 US disclosed
EP-2261299-B1 AROMATIC AMINE COMPOSITIONS AND ELECTRONIC DEVICES MADE WITH SUCH COMPOSITIONS DU PONT (US) 2016-01-06 EP disclosed
US-20150355560-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR Konica Minolta, Inc. (JP) 2015-12-10 US disclosed
US-20150355560-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR Konica Minolta, Inc. (JP) 2015-12-10 US disclosed
US-20140377694-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE Konica Minolta, Inc. (JP) 2014-12-25 US disclosed
US-20140377694-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE Konica Minolta, Inc. (JP) 2014-12-25 US disclosed
US-8716697-B2 Electronic devices made with crosslinkable compounds and copolymers E I DU PONT DE NEMOURS AND COMPANY (US) 2014-05-06 US disclosed
US-20080132622-A1 ELECTRONIC DEVICES MADE WITH CROSSLINKABLE COMPOUNDS AND COPOLYMERS E. I. DU PONT DE NEMOURS AND COMPANY 2008-06-05 US disclosed
US-7365230-B2 Cross-linkable polymers and electronic devices made with such polymers E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-04-29 US disclosed
EP-1723214-A1 AROMATIC AMINE COMPOSITIONS COMPRISING AND ELECTRONIC DEVICES MADE WITH SUCH COMPOSITIONS E.I.Du pont de nemours and company (US) 2006-11-22 EP disclosed
WO-2005083034-A1 AROMATIC AMINE COMPOSITIONS COMPRISING AND ELECTRONIC DEVICES MADE WITH SUCH COMPOSITIONS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2005-09-09 WO disclosed
US-20050184287-A1 Cross-linkable polymers and electronic devices made with such polymers LG CHEM, LTD. (KR) 2005-08-25 US disclosed
US-5080989-A Polycarbonate, solvent resistance EASTMAN KODAK COMPANY (US) 1992-01-14 US disclosed
US-4322487-A Composite electrically photosensitive particles for electrophoretic migration imaging process EASTMAN KODAK COMPANY (US) 1982-03-30 US disclosed
US-4260671-A Polycarbonate overcoats and binders for photoconductive layers and elements EASTMAN KODAK COMPANY (US) 1981-04-07 US disclosed
US-4018606-A Organic azo pigment sensitizers for photoconductive layers EASTMAN KODAK COMPANY (US) 1977-04-19 US disclosed
US-4018607-A Crystalline organic pigment sensitizers for photoconductive layers EASTMAN KODAK COMPANY (US) 1977-04-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080132622-A1 ELECTRONIC DEVICES MADE WITH CROSSLINKABLE COMPOUNDS AND COPOLYMERS GJB2, ERCC1, GJA1 HCAR2 4305/4885HDAC3 4730/4885HDAC4 4408/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.