Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11122356 | 0.81 | GFER (0.50) | HTTMAPTALDH1A1TDP1GAA | |
| SCHEMBL1672019 | 0.79 | HTT (0.65) | HTTMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL6714245 | 0.77 | MEN1 (0.54) | MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1672017 | 0.72 | HTT (1.00) | HTTMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11105710 | 0.72 | HTT (0.73) | HTTMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11161561 | 0.72 | HTT (0.73) | HTTMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6894325 | 0.72 | ALDH1A1 (0.71) | HTTMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11097076 | 0.72 | HTT (0.60) | HTTMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL11108040 | 0.72 | HTT (0.60) | HTTMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL11102744 | 0.71 | ALDH1A1 (0.78) | HTTMAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0063826-B1 | 2-AMINO-BENZOIC-ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES OR INTERMEDIATES | Dr. Karl Thomae GmbH (DE) | 1984-12-05 | — | — | EP | disclosed |
| EP-0023569-B1 | DERIVATIVES OF CARBOXYLIC ACIDS, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1983-06-22 | — | — | EP | disclosed |
| EP-0063826-A2 | 2-Amino-benzoic-acid derivatives, their preparation and their use as medicines or intermediates | Dr. Karl Thomae GmbH (DE) | 1982-11-03 | — | — | EP | disclosed |
| EP-0023569-A1 | Derivatives of carboxylic acids, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |