SCHEMBL111242

SCHEMBL111242

NC(=O)Oc1cccc2cccnc12

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.65
METAP2 P50579 1/20 0.65
METAP1 P53582 1/20 0.65
HDAC6 Q9UBN7 1/20 0.65
KDM4E B2RXH2 6/20 0.61
POLB P06746 3/20 0.61
HSP90AA1 P07900 1/20 0.60
PRSS1 P07477 1/20 0.59
ACR P10323 1/20 0.59
USP2 O75604 1/20 0.58
MAPT P10636 4/20 0.57
L3MBTL1 Q9Y468 5/20 0.57
NPSR1 Q6W5P4 4/20 0.57
MEN1 O00255 2/20 0.57
KMT2A Q03164 2/20 0.57
ALOX15 P16050 1/20 0.57
HTT P42858 1/20 0.57
PARP1 P09874 1/20 0.57
GAA P10253 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carbamic Acid SCHEMBL28080599 0.98 LMNA (0.68) LMNAMETAP2METAP1HDAC6KDM4E
SCHEMBL29903003 0.86 HSP90AA1 (0.57) LMNAMETAP2METAP1HDAC6KDM4E
SCHEMBL28459061 0.86 LMNA (0.69) LMNAMETAP2METAP1HDAC6KDM4E
SCHEMBL3415803 0.84 LMNA (0.71) LMNAMETAP2METAP1HDAC6KDM4E
SCHEMBL250301 0.83 LMNA (0.65) LMNAMETAP2METAP1HDAC6KDM4E
SCHEMBL3294621 0.83 LMNA (0.65) LMNAMETAP2METAP1HDAC6KDM4E
SCHEMBL10356985 0.83 LMNA (0.65) LMNAMETAP2METAP1HDAC6KDM4E
SCHEMBL28131091 0.82 HSP90AA1 (0.68) LMNAMETAP2METAP1HDAC6KDM4E
SCHEMBL6983292 0.82 LMNA (0.63) LMNAMETAP2METAP1HDAC6KDM4E
Hydrochloric Acid SCHEMBL2563239 0.81 LMNA (0.63) LMNAMETAP2METAP1HDAC6KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4556 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12060334-B2 3-substituted phenazine derivatives as antimicrobial agents UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2024-08-13 US claimed
EP-3715346-B1 THIAZOLYL-CONTAINING COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES DANA FARBER CANCER INST INC (US) 2024-01-03 EP claimed
EP-2970107-B1 PHOTOSWITCHABLE HDAC INHIBITORS MASSACHUSETTS GEN HOSPITAL (US) 2023-11-15 EP claimed
EP-3606528-B1 TRICYCLIC COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK3) INHIBITORS AND USES THEREOF BROAD INST INC (US) 2023-10-18 EP claimed
EP-3291676-B1 MITRAGYNINE ANALOGS AND USES THEREOF MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2022-08-17 EP claimed
US-11241435-B2 Uses of salt-inducible kinase (SIK) inhibitors for treating osteoporosis THE GENERAL HOSPITAL CORPORATION (US) 2022-02-08 US claimed
EP-3172213-B1 MACROCYCLIC KINASE INHIBITORS AND USES THEREOF DANA FARBER CANCER INST INC (US) 2021-09-22 EP claimed
EP-3092220-B1 VITAMIN C PRODRUGS AND USES THEREOF UNIV FLORIDA (US) 2021-01-20 EP claimed
US-10870651-B2 Inhibitors of cyclin-dependent kinase 7 (CDK7) DANA-FARBER CANCER INSTITUTE, INC. (US) 2020-12-22 US claimed
EP-3171874-B1 IMIDAZOLYL KINASE INHIBITORS AND USES THEREOF DANA FARBER CANCER INST INC (US) 2020-11-18 EP claimed
EP-0725106-B1 Radiation curable compositions DOW CORNING ASIA LTD (JP) 1999-11-03 EP claimed
EP-0555749-B1 Radiation sensitive compositions and processes SHIPLEY CO (US) 1999-05-19 EP claimed
US-5891529-A Radiation curable sompositions DOW CORNING ASIA, LTD. (JP) 1999-04-06 US claimed
US-5789460-A Radiation curable compositions DOW CORNING ASIA, LTD. (JP) 1998-08-04 US claimed
EP-0798341-A1 Radiation-curable composition and method for manufacturing cured-product patterns therefrom DOW CORNING ASIA, Ltd. (JP) 1997-10-01 EP claimed
EP-0725106-A2 Radiation curable compositions DOW CORNING ASIA, Ltd. (JP) 1996-08-07 EP claimed
EP-0470805-B1 Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents AMERICAN HOME PROD (US) 1994-09-07 EP claimed
US-5124455-A Enzyme inhibitors AMERICAN HOME PRODUCTS CORPORATION (US) 1992-06-23 US claimed
EP-0470805-A1 Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents AMERICAN HOME PRODUCTS CORPORATION (US) 1992-02-12 EP claimed
EP-0387510-A1 Substituted 8-carbamoyloxy-quinoline derivatives, process for their preparation and their use as pesticides BAYER AG (DE) 1990-09-19 EP claimed