Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | METAP2 | P50579 | 1/20 | 0.60 |
| ▸ | METAP1 | P53582 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.52 |
| ▸ | ACR | P10323 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457246 | 0.87 | LMNA (0.66) | LMNAL3MBTL1SMN1; SMN2GAAMETAP2 | |
| SCHEMBL10750474 | 0.84 | LMNA (0.63) | LMNAL3MBTL1SMN1; SMN2GAAMETAP2 | |
| SCHEMBL111242 | 0.82 | LMNA (0.65) | LMNAL3MBTL1SMN1; SMN2GAAMETAP2 | |
| SCHEMBL10751742 | 0.82 | LMNA (0.60) | LMNAL3MBTL1SMN1; SMN2GAAMETAP2 | |
| SCHEMBL10751830 | 0.82 | LMNA (0.60) | LMNAL3MBTL1SMN1; SMN2GAAMETAP2 | |
| SCHEMBL28459061 | 0.82 | LMNA (0.69) | LMNAL3MBTL1SMN1; SMN2GAAMETAP2 | |
| Carbamic Acid SCHEMBL28080599 | 0.81 | LMNA (0.68) | LMNAL3MBTL1SMN1; SMN2GAAMETAP2 | |
| SCHEMBL10755158 | 0.81 | LMNA (0.59) | LMNAL3MBTL1SMN1; SMN2GAAMETAP2 | |
| SCHEMBL10753183 | 0.81 | LMNA (0.78) | LMNAL3MBTL1SMN1; SMN2GAAMETAP2 | |
| SCHEMBL3415803 | 0.80 | LMNA (0.71) | LMNAL3MBTL1SMN1; SMN2GAAMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289972-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1289950-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1289953-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096304-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |
| WO-2001096296-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |
| WO-2001096323-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |