Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SKP2 | Q13309 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11825352 | 0.88 | SKP2 (0.44) | SKP2SMN1; SMN2CA2RAB9ANPC1 | |
| SCHEMBL11467020 | 0.85 | SKP2 (0.65) | SKP2SMN1; SMN2CA2HPGDRAB9A | |
| SCHEMBL8553254 | 0.83 | SKP2 (0.62) | SKP2SMN1; SMN2CA2HPGDRAB9A | |
| SCHEMBL7204931 | 0.82 | SKP2 (0.71) | SKP2SMN1; SMN2CA2HPGDRAB9A | |
| SCHEMBL30883022 | 0.82 | SKP2 (0.50) | SKP2SMN1; SMN2CA2HPGDRAB9A | |
| SCHEMBL29511379 | 0.82 | SKP2 (0.71) | SKP2SMN1; SMN2CA2HPGDRAB9A | |
| SCHEMBL3053597 | 0.82 | SKP2 (0.50) | SKP2SMN1; SMN2CA2HPGDRAB9A | |
| SCHEMBL15751289 | 0.79 | NOS3 (0.42) | SKP2SMN1; SMN2CA2HPGDRAB9A | |
| SCHEMBL23007565 | 0.79 | SKP2 (0.58) | SKP2SMN1; SMN2CA2HPGDRAB9A | |
| SCHEMBL83489 | 0.78 | SKP2 (0.61) | SKP2SMN1; SMN2CA2HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0042753-B1 | NONAPEPTIDE AND DECAPEPTIDE AGONISTS OF LUTEINIZING HORMONE RELEASING HORMONE CONTAINING HETEROCYCLIC AMINO ACID RESIDUES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOUNDS CONTAINING THEM, AND THEIR PHARMACEUTICAL USE | SYNTEX (U.S.A.) INC. (US) | 1984-03-21 | — | — | EP | disclosed |
| US-4318905-A | Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues | SYNTEX (U.S.A.) INC. (US) | 1982-03-09 | — | — | US | disclosed |
| EP-0042753-A1 | Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues, methods for their preparation, pharmaceutical compounds containing them, and their pharmaceutical use | SYNTEX (U.S.A.) INC. (US) | 1981-12-30 | — | — | EP | disclosed |