Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 5/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 6/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | PTGFR | P43088 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1113400 | 1.00 | PTGIR (0.43) | PTGIRPTGER2PTGER4PTGER3PTGER1 | |
| SCHEMBL1113407 | 1.00 | PTGIR (0.43) | PTGIRPTGER2PTGER4PTGER3PTGER1 | |
| SCHEMBL1113392 | 1.00 | PTGIR (0.43) | PTGIRPTGER2PTGER4PTGER3PTGER1 | |
| SCHEMBL7247858 | 0.87 | PTGER2 (0.37) | PTGIRPTGER2PTGER4PTGER3PTGER1 | |
| SCHEMBL7247862 | 0.87 | PTGER2 (0.37) | PTGIRPTGER2PTGER4PTGER3PTGER1 | |
| SCHEMBL7582636 | 0.86 | PTGER2 (0.46) | PTGIRPTGER2PTGER4PTGER3PTGER1 | |
| SCHEMBL2047473 | 0.84 | PDE4D (0.48) | PTGIRPTGER2PTGER4PTGER3PTGER1 | |
| SCHEMBL2047466 | 0.84 | PDE4D (0.48) | PTGIRPTGER2PTGER4PTGER3PTGER1 | |
| SCHEMBL2047465 | 0.84 | PDE4D (0.48) | PTGIRPTGER2PTGER4PTGER3PTGER1 | |
| SCHEMBL2047469 | 0.84 | PDE4D (0.48) | PTGIRPTGER2PTGER4PTGER3PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193373-B2 | Therapeutic compounds | ALLERGAN, INC. (US) | 2012-06-05 | — | — | US | disclosed |
| US-8193373-B2 | Therapeutic compounds | ALLERGAN, INC. (US) | 2012-06-05 | — | — | US | disclosed |
| US-7960378-B2 | Therapeutic compounds | ALLERGAN, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-7960378-B2 | Therapeutic compounds | ALLERGAN, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| EP-2279169-A2 | THERAPEUTIC COMPOUNDS | Allergan, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| US-20100063303-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2010-03-11 | — | — | US | disclosed |
| US-20100063303-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2010-03-11 | — | — | US | disclosed |
| US-20090239930-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2009-09-24 | — | — | US | disclosed |
| WO-2009117467-A2 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| US-20090239930-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239930-A1 | THERAPEUTIC COMPOUNDS | GBA1, ACER2, SLC10A1 | PTGIR 217/4885PTGER2 1580/4885PTGER4 1403/4885 |
| US-20100063303-A1 | THERAPEUTIC COMPOUNDS | GOT2, GOT1, ABCB1 | PTGIR 618/4885PTGER2 911/4885PTGER4 1252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.