Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 0.45 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7942550 | 0.78 | SLC6A3 (0.38) | — | |
| SCHEMBL28595968 | 0.75 | CHEK1 (0.34) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL28591880 | 0.75 | CHEK1 (0.34) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL7930899 | 0.74 | — | — | |
| SCHEMBL28673967 | 0.68 | YTHDC1 (0.37) | YTHDC1 | |
| SCHEMBL2725279 | 0.68 | — | — | |
| SCHEMBL11148023 | 0.67 | — | — | |
| SCHEMBL28932240 | 0.67 | SSTR4 (0.34) | — | |
| SCHEMBL28371325 | 0.67 | SLC6A3 (0.39) | — | |
| SCHEMBL2421840 | 0.66 | SLC6A3 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279188-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009146406-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-12-03 | — | — | WO | disclosed |