SCHEMBL7942550

SCHEMBL7942550

Clc1nc(C2CNCCO2)c2nc(Cl)nc(C3CNCCO3)c2n1

nearest known ligand 0.41

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 1/20 0.38
KCNH2 Q12809 1/20 0.38
TAAR1 Q96RJ0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7930899 0.89
SCHEMBL7937573 0.81 DRD2 (0.37)
SCHEMBL2237897 0.79 SLC6A3 (0.39) SLC6A3KCNH2TAAR1
SCHEMBL2421840 0.79 SLC6A3 (0.39) SLC6A3KCNH2TAAR1
SCHEMBL1113685 0.78 CDK1 (0.45)
SCHEMBL28932240 0.77 SSTR4 (0.34) SLC6A3KCNH2TAAR1
SCHEMBL28591880 0.76 CHEK1 (0.34) SLC6A3KCNH2TAAR1
SCHEMBL28595968 0.76 CHEK1 (0.34) SLC6A3KCNH2TAAR1
SCHEMBL27794844 0.75
SCHEMBL2725279 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6232312-B1 ADMINISTERING A COMBINATION OF INDENE AND PYRIMIDO(5,4-D)PYRIMIDINE DERIVATIVES TO TREAT PREPANCREATIC CANCER CELL PATHWAYS, INC. 2001-05-15 US disclosed