Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 9/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.52 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL43704 | 0.89 | ALDH1A1 (0.61) | CNR2TSHRMAPTMAPK1HTT | |
| Alcohol SCHEMBL9810838 | 0.86 | ALDH1A1 (0.54) | CNR2TSHRMAPTMAPK1HTT | |
| SCHEMBL28189887 | 0.86 | ALDH1A1 (0.58) | CNR2TSHRMAPTMAPK1HTT | |
| Lithium Ion SCHEMBL19732783 | 0.86 | ALDH1A1 (0.58) | CNR2TSHRMAPTMAPK1HTT | |
| Fluoride SCHEMBL11231084 | 0.86 | ALDH1A1 (0.58) | CNR2TSHRMAPTMAPK1HTT | |
| SCHEMBL21065779 | 0.86 | ALDH1A1 (0.58) | CNR2TSHRMAPTMAPK1HTT | |
| SCHEMBL3349361 | 0.86 | KEAP1 (0.51) | CNR2TSHRMAPTMAPK1HTT | |
| SCHEMBL2494123 | 0.86 | ALDH1A1 (0.61) | CNR2TSHRMAPTMAPK1HTT | |
| SCHEMBL2492417 | 0.86 | ALDH1A1 (0.61) | CNR2TSHRMAPTMAPK1HTT | |
| Nitrogen SCHEMBL28319979 | 0.84 | ALDH1A1 (0.56) | CNR2TSHRMAPTMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4423247-A | AMINOALKYLATION, NONCATALYTIC REACTION | BASF AKTIENGESELLSCHAFT (DE) | 1983-12-27 | — | — | US | disclosed |