Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PEPD | P12955 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 5/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5968636 | 0.82 | MAPT (0.59) | CA2POLBALDH1A1GAAMAPK1 | |
| SCHEMBL27072143 | 0.82 | MEN1 (0.47) | POLBGAAMEN1KMT2A | |
| SCHEMBL3129089 | 0.82 | POLB (0.61) | PEPDCA2APPCYP1A1POLB | |
| SCHEMBL1531486 | 0.82 | MAPT (0.52) | CA2POLBALDH1A1GAACA1 | |
| Hydrochloric Acid SCHEMBL10801390 | 0.81 | MAPT (0.44) | CA2APPPOLBCA1CA12 | |
| Hydrochloric Acid SCHEMBL12477635 | 0.80 | MAPT (0.50) | CA2POLBALDH1A1GAACA1 | |
| SCHEMBL9878078 | 0.79 | ALDH1A1 (0.47) | CA2POLBALDH1A1CA1CYP3A4 | |
| SCHEMBL3659518 | 0.79 | PEPD (0.54) | PEPDCA2CYP1A1POLBALDH1A1 | |
| SCHEMBL7802313 | 0.78 | POLB (0.38) | CA2POLBALDH1A1CA1CA12 | |
| SCHEMBL1161861 | 0.78 | APP (0.55) | PEPDCA2APPCYP1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101374515-A | Inhibitors of AKT activity | MERCK & CO INC (US) | 2009-02-25 | — | — | CN | claimed |
| CN-101374515-B | Inhibitors of akt activity | MERCK SHARP & DOHME | 2013-01-09 | — | — | CN | disclosed |
| CN-101374515-A | Inhibitors of AKT activity | MERCK & CO INC (US) | 2009-02-25 | — | — | CN | disclosed |
| US-4417896-A | NITRO-,AMINO-,PHENOXYALKANOLS | SOCIETE ANONYME DITE: L'OREAL (FR) | 1983-11-29 | — | — | US | disclosed |
| US-4337061-A | NITRO DYES IN AQUEOUS SOLUTION | SOCIETE ANONYME DITE: L'OREAL (FR) | 1982-06-29 | — | — | US | disclosed |