Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.37 |
| ▸ | MAOA | P21397 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HPD | P32754 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11143861 | 0.72 | MEN1 (0.39) | MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL29285290 | 0.71 | LMNA (0.48) | MAOBMAOARAB9ANPC1CASP3 | |
| SCHEMBL11154487 | 0.68 | L3MBTL1 (0.47) | MAOBRAB9ANPC1LMNACYP1A2 | |
| SCHEMBL3660167 | 0.68 | TSHR (0.48) | MAOBMAOARAB9ALMNACYP1A2 | |
| Iodide SCHEMBL11143529 | 0.68 | ALDH1A1 (0.32) | RAB9ANPC1LMNATSHR | |
| Bromide SCHEMBL11143555 | 0.67 | — | — | |
| SCHEMBL11227711 | 0.67 | MAOB (0.39) | MAOBMAOARAB9ALMNACYP1A2 | |
| Bromide SCHEMBL11140019 | 0.66 | — | — | |
| SCHEMBL3278335 | 0.64 | TSHR (0.48) | MAOBMAOARAB9ALMNACYP1A2 | |
| SCHEMBL19914172 | 0.64 | LMNA (0.52) | MAOBMAOARAB9ALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4396777-A | 1-Cycloalkyl phosphonium salts | G. D. SEARLE & CO. (US) | 1983-08-02 | — | — | US | disclosed |
| US-4336252-A | 1-Cycloalkyl phosphonium salts | G. D. SEARLE & CO. (US) | 1982-06-22 | — | — | US | disclosed |