Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | GLS | O94925 | 5/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1114331 | 0.86 | ROCK2 (0.53) | ROCK2ROCK1MAPK14GLSMMP13 | |
| SCHEMBL1114287 | 0.80 | ROCK2 (0.52) | ROCK2ROCK1MAPK14GLSMMP13 | |
| SCHEMBL1114286 | 0.76 | SMN1; SMN2 (0.52) | — | |
| SCHEMBL13447645 | 0.74 | LMNA (0.54) | ROCK2ROCK1MMP13 | |
| SCHEMBL3242530 | 0.72 | SMN1; SMN2 (0.57) | ROCK2ROCK1MAPK14 | |
| SCHEMBL1114987 | 0.72 | ROCK2 (0.51) | ROCK2ROCK1MAPK14GLSMMP13 | |
| SCHEMBL2318885 | 0.72 | GLS (0.51) | ROCK2ROCK1MAPK14GLSABCB1 | |
| SCHEMBL1114182 | 0.70 | POLB (0.52) | — | |
| SCHEMBL18352279 | 0.70 | MAPK14 (0.58) | ROCK2ROCK1MAPK14GLSMMP13 | |
| SCHEMBL29351167 | 0.70 | MAPK14 (0.58) | ROCK2ROCK1MAPK14GLSMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278879-A2 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING OXADIAZOLE DERIVATIVES | Institute for OneWorld Health (US) | 2011-02-02 | — | — | EP | claimed |
| WO-2009131957-A2 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING OXADIAZOLE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2009-10-29 | — | — | WO | claimed |