Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11148699 | 0.86 | NOD1 (0.52) | NOD1GAAUSP2ATMITK | |
| SCHEMBL11145982 | 0.78 | NOD1 (0.51) | NOD1GAAMEN1KMT2AHTR6 | |
| SCHEMBL11198021 | 0.74 | NOD1 (0.51) | NOD1GAAUSP2ATMTP53 | |
| SCHEMBL11148695 | 0.74 | NOD1 (0.50) | NOD1GAAMEN1KMT2AHTR6 | |
| SCHEMBL11156222 | 0.70 | NOD1 (0.48) | NOD1GAATP53MEN1KMT2A | |
| SCHEMBL11148594 | 0.64 | NOD1 (0.42) | NOD1ITKTP53POLBHDAC6 | |
| SCHEMBL11156172 | 0.63 | NOD1 (0.40) | NOD1ITKPOLBCYP1A2CYP2C9 | |
| SCHEMBL11156174 | 0.62 | NOD1 (0.39) | NOD1ITKPOLBCYP1A2CYP2C9 | |
| SCHEMBL25026126 | 0.62 | GAA (0.52) | GAAUSP2TP53MEN1KMT2A | |
| SCHEMBL11313286 | 0.61 | ITK (0.40) | ITKTP53CNR2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4420479-A | 1-SUBSTITUTED, 2-AMINO-BENZIMIDAZOLES | ELI LILLY AND COMPANY (US) | 1983-12-13 | — | — | US | disclosed |
| EP-0091795-A1 | Olefinic benzimidazoles | ELI LILLY AND COMPANY (US) | 1983-10-19 | — | — | EP | disclosed |