Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B13 | Q7Z5P4 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.35 |
| ▸ | STK10 | O94804 | 1/20 | 0.34 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1114610 | 0.87 | ALDH1A1 (0.34) | KDM4EALDH1A1ATMSIRT2SIRT1 | |
| SCHEMBL1114304 | 0.70 | HCRTR1 (0.36) | HSD17B13P2RX7 | |
| SCHEMBL4372432 | 0.68 | HSD17B13 (0.43) | HSD17B13KDM4EALDH1A1ATMP2RX7 | |
| SCHEMBL1114336 | 0.67 | KDM4E (0.39) | HSD17B13KDM4EALDH1A1ATMP2RX7 | |
| SCHEMBL4355638 | 0.67 | UTS2R (0.51) | HSD17B13KDM4EALDH1A1ATMP2RX7 | |
| SCHEMBL4359436 | 0.61 | GAA (0.44) | HSD17B13KDM4EALDH1A1P2RX7HSP90AA1 | |
| SCHEMBL1491106 | 0.61 | KDM4E (0.46) | KDM4EALDH1A1ATMP2RX7SIRT2 | |
| SCHEMBL3980590 | 0.59 | KDM4E (0.53) | KDM4EALDH1A1ATMP2RX7SIRT2 | |
| SCHEMBL28221686 | 0.58 | ALDH1A1 (0.48) | KDM4EALDH1A1ATMP2RX7NR1H2 | |
| SCHEMBL44837 | 0.57 | IDO1 (0.57) | KDM4EALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278879-A2 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING OXADIAZOLE DERIVATIVES | Institute for OneWorld Health (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009131957-A2 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING OXADIAZOLE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2009-10-29 | — | — | WO | disclosed |