Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ATM | Q13315 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.38 |
| ▸ | HSD17B13 | Q7Z5P4 | 7/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1114609 | 0.87 | ALDH1A1 (0.36) | KDM4EATMALDH1A1NR1H2NR1H3 | |
| SCHEMBL4372432 | 0.70 | HSD17B13 (0.43) | KDM4EATMALDH1A1NR1H2NR1H3 | |
| SCHEMBL1114553 | 0.69 | MGLL (0.39) | ALDH1A1 | |
| SCHEMBL1114833 | 0.67 | HSD17B13 (0.38) | KDM4EATMALDH1A1NR1H2NR1H3 | |
| SCHEMBL4355638 | 0.67 | UTS2R (0.51) | KDM4EATMALDH1A1HSD17B13P2RX7 | |
| SCHEMBL3980590 | 0.62 | KDM4E (0.53) | KDM4EATMALDH1A1NR1H2NR1H3 | |
| SCHEMBL15055647 | 0.61 | KMT2A (0.47) | KDM4EATMALDH1A1KMT2ATDP1 | |
| SCHEMBL4359436 | 0.61 | GAA (0.44) | KDM4EALDH1A1HSD17B13HTTP2RX7 | |
| SCHEMBL28221686 | 0.58 | ALDH1A1 (0.48) | KDM4EATMALDH1A1NR1H2NR1H3 | |
| SCHEMBL1491106 | 0.58 | KDM4E (0.46) | KDM4EATMALDH1A1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278879-A2 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING OXADIAZOLE DERIVATIVES | Institute for OneWorld Health (US) | 2011-02-02 | — | — | EP | claimed |
| WO-2009131957-A2 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING OXADIAZOLE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2009-10-29 | — | — | WO | claimed |
| EP-2278879-A2 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING OXADIAZOLE DERIVATIVES | Institute for OneWorld Health (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009131957-A2 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING OXADIAZOLE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2009-10-29 | — | — | WO | disclosed |