Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11163790 | 0.91 | ALDH1A1 (0.57) | MAPTALDH1A1SMN1; SMN2NPC1EPHX1 | |
| SCHEMBL3053531 | 0.89 | MAPT (0.66) | MAPTALDH1A1SMN1; SMN2NPC1EPHX1 | |
| SCHEMBL11154781 | 0.84 | NTRK1 (0.49) | MAPTALDH1A1SMN1; SMN2NPC1EPHX1 | |
| SCHEMBL5448142 | 0.79 | MAPT (1.00) | MAPTALDH1A1SMN1; SMN2NPC1EPHX1 | |
| SCHEMBL11161160 | 0.78 | EPHX1 (0.59) | MAPTALDH1A1SMN1; SMN2NPC1EPHX1 | |
| SCHEMBL11171201 | 0.77 | EPHX1 (0.67) | MAPTALDH1A1SMN1; SMN2NPC1EPHX1 | |
| SCHEMBL11159073 | 0.77 | EPHX1 (0.69) | MAPTALDH1A1SMN1; SMN2NPC1EPHX1 | |
| SCHEMBL11105097 | 0.77 | EPHX1 (0.66) | MAPTALDH1A1SMN1; SMN2NPC1EPHX1 | |
| SCHEMBL11157014 | 0.76 | EPHX1 (0.56) | MAPTALDH1A1SMN1; SMN2NPC1EPHX1 | |
| SCHEMBL11163863 | 0.76 | EPHX1 (0.65) | MAPTALDH1A1SMN1; SMN2NPC1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0017484-B1 | 2-IMIDAZOLINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION OF THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-04-06 | — | — | EP | disclosed |
| EP-0017484-A1 | 2-Imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-10-15 | — | — | EP | disclosed |