Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 12/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11154017 | 0.91 | MAPT (0.65) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL11154642 | 0.83 | MEN1 (0.45) | ALDH1A1LMNANPSR1MAPTMEN1 | |
| SCHEMBL11161160 | 0.81 | EPHX1 (0.59) | ALDH1A1LMNANPSR1MAPTMEN1 | |
| SCHEMBL11159073 | 0.80 | EPHX1 (0.69) | ALDH1A1LMNANPSR1MAPTALOX12 | |
| SCHEMBL11171201 | 0.80 | EPHX1 (0.67) | ALDH1A1NPSR1MAPTMEN1KMT2A | |
| SCHEMBL3053531 | 0.79 | MAPT (0.66) | ALDH1A1LMNANPSR1MAPTMEN1 | |
| SCHEMBL11105097 | 0.79 | EPHX1 (0.66) | ALDH1A1LMNANPSR1MAPTMEN1 | |
| SCHEMBL11157014 | 0.79 | EPHX1 (0.56) | ALDH1A1LMNANPSR1MAPTMEN1 | |
| SCHEMBL11163863 | 0.79 | EPHX1 (0.65) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL11162636 | 0.78 | ALDH1A1 (0.67) | ALDH1A1LMNANPSR1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0017484-B1 | 2-IMIDAZOLINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION OF THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-04-06 | — | — | EP | disclosed |
| EP-0017484-A1 | 2-Imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-10-15 | — | — | EP | disclosed |