Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 16/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 1.00 |
| ▸ | NPC1 | O15118 | 3/20 | 1.00 |
| ▸ | EPHX1 | P07099 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.78 |
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 3/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2565238 | 0.86 | HDAC8 (0.76) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14096655 | 0.86 | MAPT (1.00) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5462203 | 0.83 | MAPT (0.79) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4252909 | 0.81 | HDAC8 (0.76) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5448046 | 0.81 | ALDH1A1 (1.00) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3053531 | 0.80 | MAPT (0.66) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL11154017 | 0.79 | MAPT (0.65) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14096025 | 0.79 | MAPT (0.73) | MAPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| N-(Phenylcarbamothioyl)Benzamide SCHEMBL2341910 | 0.79 | EPHX1 (1.00) | ALDH1A1SMN1; SMN2RAB9ANPC1EPHX1 | |
| SCHEMBL8616503 | 0.77 | EPHX1 (0.83) | ALDH1A1SMN1; SMN2RAB9ANPC1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2718290-B1 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | CLEVEXEL PHARMA (FR) | 2016-05-04 | — | — | EP | disclosed |
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |
| US-20070040151-A1 | Two-component initiator system (amine-free) with very good storage stability and particular suitability for acid systems | HERAEUS KULZER GMBH (DE) | 2007-02-22 | — | — | US | disclosed |