Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 4/20 | 0.49 |
| ▸ | RARG | P13631 | 4/20 | 0.49 |
| ▸ | RARA | P10276 | 3/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 4/20 | 0.47 |
| ▸ | RXRB | P28702 | 4/20 | 0.47 |
| ▸ | RXRG | P48443 | 3/20 | 0.47 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TYR | P14679 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28945602 | 0.99 | RARB (0.50) | RARBRARGRARAESR1ESR2 | |
| SCHEMBL14092702 | 0.91 | NR1H4 (0.47) | RARBRARGRARAESR1ESR2 | |
| Bicarbonate SCHEMBL11155617 | 0.89 | ESR1 (0.43) | RARBRARGRARAESR1ESR2 | |
| SCHEMBL9070248 | 0.89 | RARB (0.47) | RARBRARGRARAESR1ESR2 | |
| SCHEMBL6674203 | 0.88 | ESR1 (0.57) | ESR1ESR2RXRARXRBRXRG | |
| SCHEMBL7766099 | 0.84 | WDR5 (0.47) | RARBRARGRARARXRARXRB | |
| SCHEMBL25492650 | 0.83 | ALDH1A1 (0.53) | RARBRARGRARARXRARXRB | |
| SCHEMBL10904763 | 0.82 | NR1H4 (0.51) | RARBRARGRARARXRARXRB | |
| SCHEMBL5016004 | 0.81 | SERPINE1 (0.55) | ESR1ESR2NR1H4ALDH1A1TYR | |
| SCHEMBL30899212 | 0.81 | APEX1 (0.50) | RXRARXRBRXRGNR1H4TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4398018-A | Temperature stable thermotropic poly(ester carbonate) derived from t-butylhydroquinone | ALLIED CORPORATION (US) | 1983-08-09 | — | — | US | claimed |