Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | MC5R | P33032 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28978028 | 0.81 | MAPK1 (0.43) | PARP1NPC1GPR119MC4RMC5R | |
| SCHEMBL28067177 | 0.79 | GPR119 (0.47) | PARP1NPC1GPR119MC4RMC5R | |
| SCHEMBL17560446 | 0.79 | PARP1 (0.41) | LMNANPSR1PARP1NPC1GPR119 | |
| SCHEMBL30740797 | 0.78 | PARP1 (0.38) | LMNANPSR1PARP1NPC1POLB | |
| SCHEMBL31218680 | 0.75 | DDB1 (0.39) | PARP1NPC1NR1H2MC4RMC5R | |
| SCHEMBL8554593 | 0.74 | PARP1 (0.43) | LMNANPSR1PARP1NPC1NR1H2 | |
| SCHEMBL17560433 | 0.74 | PARP1 (0.43) | LMNANPSR1PARP1NPC1NR1H2 | |
| SCHEMBL8554343 | 0.74 | PARP1 (0.43) | LMNANPSR1PARP1NPC1NR1H2 | |
| SCHEMBL990488 | 0.73 | CA1 (0.40) | HSD11B1L3MBTL1 | |
| SCHEMBL29072017 | 0.73 | PARP1 (0.39) | LMNANPSR1PARP1NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606265-B1 | 2, 4- DI (PHENYLAMINO) PYRIMIDINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2011-02-02 | — | — | EP | disclosed |