Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAPDH | P04406 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11072010 | 0.84 | ALDH1A1 (0.45) | ALDH1A1MAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL11075921 | 0.82 | MAPT (0.59) | ALDH1A1MAPTPOLBGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11377545 | 0.70 | SMN1; SMN2 (0.59) | ALDH1A1MAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL5795262 | 0.70 | — | — | |
| SCHEMBL161122 | 0.65 | ADRA2C (0.57) | ALDH1A1MAPTGAASMN1; SMN2KMT2A | |
| SCHEMBL6251508 | 0.65 | ALDH1A1 (0.54) | ALDH1A1GAACYP3A4KMT2AMEN1 | |
| SCHEMBL11376502 | 0.63 | MAPT (0.61) | ALDH1A1MAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL4033039 | 0.63 | CHKA (0.61) | MAPTGAASMN1; SMN2CYP3A4CYP1A2 | |
| SCHEMBL28923884 | 0.63 | MAPT (0.55) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL10660228 | 0.63 | L3MBTL1 (0.60) | ALDH1A1MAPTPOLBGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0006711-B1 | HETEROCYCLIC DERIVATIVES OF (4-PHENYLPIPERAZIN-1-YL-ARYLOXYMETHYL-1,3-DIOXOLAN-2-YL)-METHYL-1H-IMIDAZOLES AND 1H-1,2,4-TRIAZOLES, PROCESSES FOR PREPARING THEM AND COMPOSITIONS CONTAINING THEM | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-10-26 | — | — | EP | disclosed |