SCHEMBL11155643

SCHEMBL11155643

Nc1cc(OCC(F)(F)F)c(N)c2c1C(=O)c1ccccc1C2=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.47
KMT2A Q03164 5/20 0.47
MAPT P10636 4/20 0.47
THRB P10828 3/20 0.47
KDM4E B2RXH2 2/20 0.47
USP2 O75604 2/20 0.47
MAPK1 P28482 2/20 0.47
NPSR1 Q6W5P4 2/20 0.47
MCL1 Q07820 2/20 0.47
GRK6 P43250 1/20 0.47
PKM P14618 1/20 0.47
ALDH1A1 P00352 3/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
HSP90AA1 P07900 1/20 0.45
HSP90AB1 P08238 1/20 0.45
G6PD P11413 1/20 0.45
ALOX15 P16050 1/20 0.45
CASP1 P29466 1/20 0.45
HSD17B10 Q99714 1/20 0.45
ADORA2A P29274 6/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11156068 0.86 MEN1 (0.44) MEN1KMT2AMAPTTHRBKDM4E
SCHEMBL10815326 0.78 ADORA2A (0.49) MEN1KMT2AMAPTTHRBKDM4E
SCHEMBL460432 0.76 MAPT (0.66) MEN1KMT2AMAPTTHRBKDM4E
SCHEMBL13671210 0.76 TERT (0.48) MEN1KMT2AMAPTTHRBKDM4E
SCHEMBL13352362 0.75 MEN1 (0.54) MEN1KMT2AMAPTTHRBKDM4E
SCHEMBL92415 0.74 ADORA2A (0.66) MEN1KMT2AMAPTTHRBKDM4E
SCHEMBL19486324 0.73 MEN1 (0.39) MEN1KMT2AMAPTTHRBKDM4E
SCHEMBL11345777 0.72 MEN1 (0.61) MEN1KMT2AMAPTTHRBKDM4E
SCHEMBL20991740 0.72 MEN1 (0.40) MEN1KMT2AMAPTTHRBKDM4E
SCHEMBL10817109 0.71 ADORA2A (0.55) MEN1KMT2AMAPTTHRBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4385900-A POLYAMIDES AND POLYESTERS CIBA-GEIGY AG (CH) 1983-05-31 US disclosed