Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | THRB | P10828 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | GRK6 | P43250 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.49 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | FGR | P09769 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL460432 | 0.80 | MAPT (0.66) | MEN1KMT2AMAPTTHRBMAPK1 | |
| SCHEMBL11345777 | 0.79 | MEN1 (0.61) | MEN1KMT2AMAPTTHRBMAPK1 | |
| SCHEMBL92415 | 0.77 | ADORA2A (0.66) | MEN1KMT2AMAPTTHRBMAPK1 | |
| SCHEMBL11023123 | 0.77 | MEN1 (0.55) | MEN1KMT2AMAPTTHRBMAPK1 | |
| SCHEMBL8729470 | 0.77 | MEN1 (0.51) | MEN1KMT2AMAPTTHRBMAPK1 | |
| SCHEMBL11155643 | 0.75 | MEN1 (0.47) | MEN1KMT2AMAPTTHRBMAPK1 | |
| SCHEMBL10906307 | 0.75 | ADORA2A (0.52) | MEN1KMT2AMAPTTHRBMAPK1 | |
| SCHEMBL8734315 | 0.75 | ADORA2A (0.52) | MEN1KMT2AMAPTTHRBMAPK1 | |
| SCHEMBL10817109 | 0.75 | ADORA2A (0.55) | MEN1KMT2AMAPTTHRBMAPK1 | |
| SCHEMBL11759211 | 0.74 | ADORA2A (0.45) | MEN1KMT2AMAPTTHRBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130505-A1 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | UNIVERSITY OF ROCHESTER (US) | 2010-05-27 | — | — | US | disclosed |
| WO-2009020677-A9 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | UNIV ROCHESTER (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009020677-A2 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | UNIVERSITY OF ROCHESTER (US) | 2009-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130505-A1 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | GNAI1, GNAI3, GNAI2 | MEN1 3515/4885KMT2A 4394/4885MAPT 3637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.