Sugi Predict

Sugi Predict / Compounds / SCHEMBL1115840

SCHEMBL1115840

SCHEMBL1115840

Nc1cc2oc(=O)[nH]c2cc1Cl

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMO O15229 1/20 0.72
▸ NOS1 P29475 4/20 0.53
▸ NOS3 P29474 3/20 0.53
▸ NOS2 P35228 3/20 0.53
▸ LMNA P02545 2/20 0.53
▸ CYP1A2 P05177 2/20 0.53
▸ TSHR P16473 2/20 0.53
▸ THPO P40225 2/20 0.53
▸ BLM P54132 2/20 0.53
▸ ADRA2A P08913 1/20 0.53
▸ NPSR1 Q6W5P4 1/20 0.53
▸ LRRK2 Q5S007 1/20 0.42
▸ CA12 O43570 1/20 0.41
▸ CA9 Q16790 1/20 0.41
▸ OGT O15294 1/20 0.41
▸ KDM4E B2RXH2 2/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ GRIA1 P42261 2/20 0.40
▸ CACNG8 Q8WXS5 1/20 0.40
▸ GAA P10253 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11045421 0.93 KMO (0.72) KMONOS1NOS3NOS2LMNA
SCHEMBL11256608 0.84 KMO (1.00) KMONOS1NOS3NOS2LMNA
SCHEMBL9680309 0.84 KMO (0.59) KMONOS1NOS3NOS2LMNA
SCHEMBL5536703 0.78 KMO (0.72) KMONOS1NOS3NOS2LMNA
SCHEMBL6164657 0.78 KMO (0.72) KMONOS1NOS3NOS2LMNA
SCHEMBL528197 0.78 KMO (0.72) KMONOS1NOS3NOS2LMNA
SCHEMBL522196 0.78 NOS1 (0.53) KMONOS1NOS3NOS2LMNA
SCHEMBL7067142 0.78 KMO (0.52) KMONOS1NOS3NOS2LMNA
Bromchlorenone SCHEMBL637478 0.78 KMO (0.72) KMONOS1NOS3NOS2LMNA
SCHEMBL5536706 0.78 KMO (0.72) KMONOS1NOS3NOS2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4997920-A Dyeing polyolefins CIBA-GEIGY CORPORATION (US) 1991-03-05 — — US claimed
US-4670486-A Polymer composition pigmented with copper or nickel complexes of ligands containing a semicarbazone moiety CIBA-GEIGY CORPORATION (US) 1987-06-02 — — US claimed
US-10752624-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2020-08-25 — — US disclosed
US-20180305356-A1 NOVEL KINASE INHIBITORS ORIGENIS GMBH (DE) 2018-10-25 — — US disclosed
US-10000482-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2018-06-19 — — US disclosed
US-9637491-B2 Pyrazolo[4,3-D]pyrimidines as kinase inhibitors ORIGENIS GMBH (DE) 2017-05-02 — — US disclosed
US-20150266882-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2015-09-24 — — US disclosed
US-20150259340-A1 NOVEL KINASE INHIBITORS ORIGENIS GMBH (DE) 2015-09-17 — — US disclosed
WO-2014060112-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2014-04-24 — — WO disclosed
US-8262949-B2 Long wavelength shifted benzotriazole uv-absorbers and their use BASF SE (DE) 2012-09-11 — — US disclosed
US-8262949-B2 Long wavelength shifted benzotriazole uv-absorbers and their use BASF SE (DE) 2012-09-11 — — US disclosed
US-4220586-A FASTNESS TO LIGHT, OVER-LACQUERING, MIGRATION, WEATHERING, AND HEAT CIBA-GEIGY CORPORATION (US) 1980-09-02 — — US disclosed
EP-0006154-A1 Monoazo pigments and their use in colouring high molecular-weight organic material CIBA-GEIGY AG (CH) 1980-01-09 — — EP disclosed
EP-0000737-A1 Monoazo pigments of the acetoacetylamino benzimidazolone series, their preparation and their use for colouring organic material of high molecular weight CIBA-GEIGY AG (CH) 1979-02-21 — — EP disclosed
US-4116959-A ISOINDOLINE PIGMENTS CIBA-GEIGY CORPORATION (US) 1978-09-26 — — US disclosed
US-4088641-A YELLOW TO RED SHADES CIBA-GEIGY CORPORATION (US) 1978-05-09 — — US disclosed
US-4052410-A YELLOW, PLASTICS, LACQUERS CIBA-GEIGY CORPORATION (US) 1977-10-04 — — US disclosed
US-4012371-A Benzinaldazolyl-, quinolonyl-, or phenmorpholonylazo-3-cyano-4-methyl-1,2-[1',2']-benz-[4',5']-imidazolo-6-hydroxypyridine colorants CIBA-GEIGY CORPORATION (US) 1977-03-15 — — US disclosed
US-3979386-A YELLOW, COLORFASTNESS CIBA-GEIGY CORPORATION (US) 1976-09-07 — — US disclosed
US-3956266-A DISAZO DYES CIBA-GEIGY CORPORATION (US) 1976-05-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150259340-A1 NOVEL KINASE INHIBITORS LRRK2, MYLK2, MYLK KMO 462/4885NOS1 1289/4885NOS3 1955/4885
US-20150266882-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS LRRK2, MYLK2, MYLK KMO 197/4885NOS1 2068/4885NOS3 1854/4885
US-20180305356-A1 NOVEL KINASE INHIBITORS LRRK2, MYLK2, MYLK KMO 462/4885NOS1 1289/4885NOS3 1955/4885
US-10000482-B2 Kinase inhibitors LRRK2, MYLK2, MYLK KMO 386/4885NOS1 1266/4885NOS3 1832/4885
US-10752624-B2 Kinase inhibitors LRRK2, MYLK2, MYLK KMO 386/4885NOS1 1266/4885NOS3 1832/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.