SCHEMBL11158581

SCHEMBL11158581

COP(=S)(c1ccccc1)N(C)SN(C)C(=O)F

nearest known ligand 0.33

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.33
KMT2A Q03164 2/20 0.31
ALDH1A1 P00352 1/20 0.31
PKM P14618 1/20 0.31
CA12 O43570 1/20 0.31
CA9 Q16790 1/20 0.31
CA2 P00918 1/20 0.30
MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11151893 0.84 MEN1 (0.30) POLBKMT2AMEN1
SCHEMBL11414335 0.77 MEN1 (0.33) KMT2AMEN1
SCHEMBL11152205 0.77 SRC (0.35) KMT2AALDH1A1PKMMEN1
SCHEMBL11152478 0.75 SRC (0.36) KMT2AALDH1A1PKMMEN1
SCHEMBL11151462 0.75
SCHEMBL11154367 0.74 LMNA (0.36) KMT2AALDH1A1MEN1
SCHEMBL11159437 0.74 L3MBTL1 (0.38) POLBKMT2AALDH1A1CA12CA9
SCHEMBL11150365 0.73 L3MBTL1 (0.40) KMT2AALDH1A1PKMCA12CA9
SCHEMBL11154937 0.73
SCHEMBL11148723 0.71 L3MBTL1 (0.37) KMT2AALDH1A1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4234521-A Phosphorus derivatives of aminothiocarbamoyl halides THE UPJOHN COMPANY (US) 1980-11-18 US claimed
US-4405796-A Processes for making phosphorus derivatives of aminothiomethylcarbamates THE UPJOHN COMPANY (US) 1983-09-20 US disclosed
US-4354975-A Processes for making phosphorus derivatives of aminothiomethylcarbamates THE UPJOHN COMPANY (US) 1982-10-19 US disclosed
US-4336207-A Phosphorus derivatives of aminothiocarbamoyl halides THE UPJOHN COMPANY (US) 1982-06-22 US disclosed
US-4279840-A Processes for making phosphorus containing aminothiocarbamoyl halides THE UPJOHN COMPANY (US) 1981-07-21 US disclosed
US-4279839-A Processes for making phosphorus containing aminothiocarbamoyl halides THE UPJOHN COMPANY (US) 1981-07-21 US disclosed
US-4234521-A Phosphorus derivatives of aminothiocarbamoyl halides THE UPJOHN COMPANY (US) 1980-11-18 US disclosed