Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | GFER | P55789 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 5/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10670193 | 0.76 | ALPL (0.47) | DAOCYP1A2 | |
| SCHEMBL11160295 | 0.75 | GFER (0.53) | HPGDGFERL3MBTL1MMP2PLA2G7 | |
| SCHEMBL10736202 | 0.70 | GFER (0.57) | HPGDGFERL3MBTL1PLA2G7ALDH1A1 | |
| SCHEMBL12955389 | 0.70 | AR (0.72) | CYP3A4CYP2C9 | |
| SCHEMBL10618910 | 0.69 | PLA2G7 (0.71) | PLA2G7 | |
| SCHEMBL16110564 | 0.68 | PRMT5 (0.53) | CYP3A4CYP2C9 | |
| SCHEMBL6263112 | 0.67 | SMN1; SMN2 (0.58) | HPGDALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL16136132 | 0.67 | PARP1 (0.53) | — | |
| SCHEMBL16110172 | 0.67 | PARP1 (0.53) | CYP3A4CYP2C9 | |
| SCHEMBL1252561 | 0.67 | PARP1 (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4374836-A | Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES LTD. (GB) | 1983-02-22 | — | — | US | disclosed |
| US-4220767-A | HISTAMINE ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-09-02 | — | — | US | disclosed |
| EP-0010894-A1 | Antisecretory heterocyclic guanidine derivatives, process for their manufacture and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-05-14 | — | — | EP | disclosed |
| US-4185103-A | ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-01-22 | — | — | US | disclosed |