Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11160250 | 0.77 | MAPT (0.47) | KDM4EALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL7507341 | 0.77 | PDE10A (0.48) | KDM4EALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL11162923 | 0.76 | MEN1 (0.48) | KDM4ESMN1; SMN2ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL11412801 | 0.75 | HPGD (0.46) | KDM4ESMN1; SMN2ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL4098956 | 0.72 | ADORA2A (0.49) | KDM4ESMN1; SMN2ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL11403379 | 0.71 | L3MBTL1 (0.54) | KDM4ESMN1; SMN2ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL11162029 | 0.71 | ALDH1A1 (0.63) | KDM4ESMN1; SMN2ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL2878048 | 0.71 | ADORA1 (0.44) | KDM4ESMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL4864986 | 0.71 | PDE5A (0.64) | KDM4ESMN1; SMN2ALDH1A1LMNAHIF1A | |
| SCHEMBL11203920 | 0.70 | ADORA2A (0.68) | KDM4EALDH1A1LMNAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0018139-B1 | PYRIDO (2,3-D) PYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR PREPARING THE PYRIDO (2,3-D) PYRIMIDINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-05-04 | — | — | EP | disclosed |
| US-4301281-A | 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]-pyrimidine-6-carboxylic acid amides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-11-17 | — | — | US | disclosed |
| US-4255568-A | ANTIALLERGENS AND ANTISECRETORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| US-4236004-A | 2-Alkylsulphonyl-7,8-dihydro-5-hydroxy-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-11-25 | — | — | US | disclosed |
| US-4233446-A | 5-Chloro-7,8-dihydro-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-11-11 | — | — | US | disclosed |
| EP-0018139-A2 | Pyrido (2,3-d) pyrimidine derivatives, pharmaceutical compositions containing them and processes for preparing the pyrido (2,3-d) pyrimidine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-10-29 | — | — | EP | disclosed |
| US-4215216-A | 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-07-29 | — | — | US | disclosed |