Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696235 | 0.75 | TP53 (0.57) | HPGDALDH1A1L3MBTL1KDM4ETP53 | |
| SCHEMBL11160504 | 0.75 | KDM4E (0.50) | HPGDALDH1A1L3MBTL1KDM4ELMNA | |
| SCHEMBL9432628 | 0.68 | RAB9A (0.50) | HPGDALDH1A1L3MBTL1KDM4ELMNA | |
| SCHEMBL10824003 | 0.67 | KDM4E (0.42) | ALDH1A1L3MBTL1KDM4ELMNATP53 | |
| SCHEMBL10566676 | 0.65 | HPGD (0.33) | HPGDTP53 | |
| SCHEMBL15661369 | 0.64 | SRC (0.42) | HTT | |
| SCHEMBL4763576 | 0.64 | CSNK1A1 (0.44) | HPGDALDH1A1L3MBTL1TP53MEN1 | |
| SCHEMBL6864300 | 0.62 | PGK1 (0.45) | HPGDALDH1A1KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL10749903 | 0.61 | TGFBR1 (0.39) | HPGDALDH1A1L3MBTL1TDP1MEN1 | |
| SCHEMBL9619229 | 0.61 | GAA (0.44) | ALDH1A1LMNASMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4245094-A | 5-Amino-2,8-dialkyl-7,8-dihydro-7-oxo-pyrido-[2,3-d]pyrimidine-6 carboxylic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-01-13 | — | — | US | disclosed |