Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116169 | 1.00 | CA2 (0.42) | CA2PIK3CGPIK3CADYRK3PIM1 | |
| SCHEMBL1116161 | 0.81 | HTR2A (0.42) | CA2PIK3CGPIK3CADYRK3PIM1 | |
| SCHEMBL1116264 | 0.75 | HTR2A (0.54) | CA2PIK3CGHTR2ACA1CLK1 | |
| SCHEMBL1116262 | 0.75 | HTR2A (0.54) | CA2PIK3CGHTR2ACA1CLK1 | |
| SCHEMBL1228309 | 0.74 | BRAF (0.60) | PIK3CGMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL1116165 | 0.74 | CA2 (0.38) | CA2DYRK3PIM1CSNK2A2CSNK2B | |
| SCHEMBL1228305 | 0.74 | BRAF (0.60) | PIK3CGMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL1116220 | 0.72 | DYRK2 (0.64) | PIK3CGPIK3CADYRK3PIM1CSNK2A2 | |
| SCHEMBL1116223 | 0.72 | DYRK2 (0.64) | PIK3CGPIK3CADYRK3PIM1CSNK2A2 | |
| SCHEMBL6859360 | 0.72 | GSK3A (0.43) | PIK3CGPIK3CAMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011015646-A2 | FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS | NOSCIRA, S.A. (ES) | 2011-02-10 | — | — | WO | disclosed |
| EP-2281824-A1 | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders | NOSCIRA, S.A. (ES) | 2011-02-09 | — | — | EP | disclosed |