Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.37 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.36 |
| ▸ | DDX3X | O00571 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13587229 | 0.90 | P2RX7 (0.41) | MAPTPRSS12DDX3XTAS2R14IRAK4 | |
| SCHEMBL1115897 | 0.89 | MAPT (0.42) | MAPTMAPK10IMPDH2SRCKDM4E | |
| SCHEMBL1116255 | 0.86 | MAPT (0.46) | MAPTDDX3XTSHRAKR1C3PBRM1 | |
| SCHEMBL1116018 | 0.85 | MAPT (0.42) | MAPTMAPK10IMPDH2IRAK4SRC | |
| SCHEMBL12856619 | 0.84 | MAPT (0.44) | MAPTDDX3XTSHRAKR1C3PBRM1 | |
| SCHEMBL12856631 | 0.84 | MAPT (0.44) | MAPTDDX3XTSHRAKR1C3PBRM1 | |
| SCHEMBL1116024 | 0.84 | MAPT (0.44) | MAPTDDX3XTSHRAKR1C3PBRM1 | |
| SCHEMBL2926922 | 0.84 | MAPT (0.44) | MAPTDDX3XTSHRAKR1C3PBRM1 | |
| SCHEMBL12856603 | 0.82 | MAPT (0.46) | MAPTMAPK10DDX3XTSHRAKR1C3 | |
| SCHEMBL1115902 | 0.81 | FABP3 (0.45) | MAPTAKR1C3POLBMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2281819-A1 | Benzimidazolyl or benzoxazolyl derivatives | Novartis AG (CH) | 2011-02-09 | — | — | EP | disclosed |
| US-20090298824-A1 | Organic compounds | PRESS NEIL J | 2009-12-03 | — | — | US | disclosed |
| US-20090298824-A1 | Organic compounds | PRESS NEIL J | 2009-12-03 | — | — | US | disclosed |
| US-20090298824-A1 | Organic compounds | PRESS NEIL J | 2009-12-03 | — | — | US | disclosed |
| EP-1709015-A1 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005070906-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2005-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298824-A1 | Organic compounds | CXCR2, CXCR3, CXCR1 | MAPT 4012/4885MAPK10 1647/4885IMPDH2 3390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.