Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11154781 | 0.89 | NTRK1 (0.49) | MEN1KMT2ANPSR1LMNAMAPT | |
| SCHEMBL11163790 | 0.83 | ALDH1A1 (0.57) | MEN1KMT2ANPSR1LMNAL3MBTL1 | |
| SCHEMBL11170685 | 0.77 | NPSR1 (0.50) | MEN1KMT2ANPSR1LMNAL3MBTL1 | |
| SCHEMBL11170669 | 0.76 | NPSR1 (0.71) | MEN1KMT2ANPSR1LMNAL3MBTL1 | |
| SCHEMBL11163831 | 0.76 | MAPT (0.49) | MEN1KMT2ANPSR1LMNAL3MBTL1 | |
| SCHEMBL11161437 | 0.75 | ALDH1A1 (0.49) | MEN1KMT2ANPSR1LMNAL3MBTL1 | |
| SCHEMBL7815135 | 0.75 | ADRA2C (0.59) | MEN1KMT2ANPSR1LMNAL3MBTL1 | |
| SCHEMBL11154017 | 0.74 | MAPT (0.65) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL11161355 | 0.74 | PARP10 (0.51) | NPSR1LMNAL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL11168538 | 0.73 | MAPT (0.46) | MEN1KMT2ANPSR1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0017484-B1 | 2-IMIDAZOLINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION OF THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-04-06 | — | — | EP | disclosed |
| EP-0017484-A1 | 2-Imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-10-15 | — | — | EP | disclosed |