Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11433161 | 0.87 | ALDH1A1 (0.45) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL22339032 | 0.86 | TAS2R38 (0.42) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL11163219 | 0.82 | ALDH1A1 (0.51) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL16119714 | 0.81 | MAPT (0.47) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL28294431 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL11165601 | 0.80 | EPHX1 (0.69) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL29998429 | 0.76 | ALDH1A1 (0.66) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL194142 | 0.76 | ALDH1A1 (0.66) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL11163432 | 0.76 | GAA (0.47) | ALDH1A1MAPTGAAMEN1KMT2A | |
| SCHEMBL7815135 | 0.76 | ADRA2C (0.59) | ALDH1A1MAPTGAAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0017484-B1 | 2-IMIDAZOLINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION OF THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-04-06 | — | — | EP | disclosed |
| EP-0017484-A1 | 2-Imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-10-15 | — | — | EP | disclosed |