Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Glaucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 14/20 | 0.97 |
| ▸ | HTR2B | P41595 | 13/20 | 0.97 |
| ▸ | HTR2C | P28335 | 13/20 | 0.97 |
| ▸ | HTR7 | P34969 | 12/20 | 0.97 |
| ▸ | HTR1A | P08908 | 11/20 | 0.97 |
| ▸ | DRD1 | P21728 | 6/20 | 0.97 |
| ▸ | DRD2 | P14416 | 5/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.97 |
| ▸ | TDP2 | O95551 | 2/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.97 |
| ▸ | MAPT | P10636 | 2/20 | 0.97 |
| ▸ | CASP3 | P42574 | 2/20 | 0.97 |
| ▸ | RAD52 | P43351 | 2/20 | 0.97 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.97 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.97 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.97 |
| ▸ | PTPRCAP | Q14761 | 1/20 | 0.97 |
| ▸ | APAF1 | O14727 | 1/20 | 0.95 |
| ▸ | HPGD | P15428 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glaucine SCHEMBL146441 | 0.99 | HTR2A (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| Glaucine SCHEMBL30213021 | 0.99 | HTR2A (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| Glaucine SCHEMBL3040938 | 0.99 | HTR2A (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| Glaucine SCHEMBL29735463 | 0.99 | HTR2A (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| Glaucine SCHEMBL11158386 | 0.97 | KDM4E (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| Glaucine SCHEMBL11249152 | 0.97 | KDM4E (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| Glaucine SCHEMBL4312401 | 0.93 | HTR2A (0.88) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| Glaucine SCHEMBL7389697 | 0.92 | HTR2B (0.86) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| SCHEMBL4854015 | 0.90 | HTR7 (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| SCHEMBL30475142 | 0.90 | HTR7 (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4370331-A | L-Glaucine containing composition for cough relief | KARL O. HELM AKTIENGESELLSCHAFT (DE) | 1983-01-25 | — | — | US | disclosed |
| US-4279914-A | 1-GLAUCINE OR TETRAHYDROXYAPORPHINE, ANTICOAGULANTS | HERMANN GOTTFRIED SCHNABEL FA. (DE) | 1981-07-21 | — | — | US | disclosed |