Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Glaucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.71 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.71 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.71 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.71 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.71 |
| ▸ | HTR2A | P28223 | 12/20 | 0.88 |
| ▸ | HTR2B | P41595 | 11/20 | 0.88 |
| ▸ | HTR2C | P28335 | 11/20 | 0.88 |
| ▸ | HTR7 | P34969 | 10/20 | 0.88 |
| ▸ | HTR1A | P08908 | 9/20 | 0.88 |
| ▸ | DRD1 | P21728 | 6/20 | 0.88 |
| ▸ | DRD2 | P14416 | 5/20 | 0.88 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.88 |
| ▸ | MAPT | P10636 | 3/20 | 0.88 |
| ▸ | TDP2 | O95551 | 2/20 | 0.88 |
| ▸ | CASP3 | P42574 | 2/20 | 0.88 |
| ▸ | RAD52 | P43351 | 2/20 | 0.88 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.88 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glaucine SCHEMBL11251386 | 0.94 | HTR2A (0.83) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| Glaucine SCHEMBL146441 | 0.94 | HTR2A (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| Glaucine SCHEMBL29735463 | 0.94 | HTR2A (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| Glaucine SCHEMBL30213021 | 0.94 | HTR2A (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| Glaucine SCHEMBL3040938 | 0.94 | HTR2A (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| Glaucine SCHEMBL11158386 | 0.93 | KDM4E (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| Glaucine SCHEMBL11249152 | 0.93 | KDM4E (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| Glaucine SCHEMBL11166124 | 0.93 | HTR2A (0.97) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| SCHEMBL4854015 | 0.88 | HTR7 (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A | |
| SCHEMBL30475142 | 0.88 | HTR7 (1.00) | HTR2AHTR2BHTR2CHTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4315010-A | ANTITUSSIVE | THE DOW CHEMICAL COMPANY (US) | 1982-02-09 | — | — | US | claimed |
| US-10877035-B2 | Advanced drug development and manufacturing | ICAGEN, LLC (US) | 2020-12-29 | — | — | US | disclosed |
| US-20150309021-A1 | Advanced Drug Development and Manufacturing | LOS ALAMOS NATIONAL SECURITY, LLC | 2015-10-29 | — | — | US | disclosed |
| EP-2511844-B1 | X-ray microscope | XRPRO SCIENCES INC (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-2511844-A2 | Advanced drug development and manufacturing | Los Alamos National Security, LLC (US) | 2012-10-17 | — | — | EP | disclosed |
| EP-2084519-B1 | X-RAY FLUORESCENCE ANALYSIS METHOD | LOS ALAMOS NAT SECURITY LLC (US) | 2012-08-01 | — | — | EP | disclosed |
| EP-2084519-A2 | ADVANCED DRUG DEVELOPMENT AND MANUFACTURING | Los Alamos National Security, LLC (US) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008127291-A2 | ADVANCED DRUG DEVELOPMENT AND MANUFACTURING | LOS ALAMOS NATIONAL SECURITY, LLC (US) | 2008-10-23 | — | — | WO | disclosed |
| US-20080220441-A1 | Advanced drug development and manufacturing | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-09-11 | — | — | US | disclosed |
| US-4358592-A | Glaucine phosphate chunky prismatic crystals | THE DOW CHEMICAL COMPANY & MERRELL DOW PHARMACEUTICALS INCORPORATED (US) | 1982-11-09 | — | — | US | disclosed |
| US-4358592-A | Glaucine phosphate chunky prismatic crystals | THE DOW CHEMICAL COMPANY & MERRELL DOW PHARMACEUTICALS INCORPORATED (US) | 1982-11-09 | — | — | US | disclosed |
| US-4358592-A | Glaucine phosphate chunky prismatic crystals | THE DOW CHEMICAL COMPANY & MERRELL DOW PHARMACEUTICALS INCORPORATED (US) | 1982-11-09 | — | — | US | disclosed |
| US-4315010-A | ANTITUSSIVE | THE DOW CHEMICAL COMPANY (US) | 1982-02-09 | — | — | US | disclosed |
| US-4315010-A | ANTITUSSIVE | THE DOW CHEMICAL COMPANY (US) | 1982-02-09 | — | — | US | disclosed |
| US-4183939-A | Glaucine analgesic method | THE DOW CHEMICAL COMPANY (US) | 1980-01-15 | — | — | US | disclosed |