Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Glaucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 11/20 | 0.97 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.77 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.77 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.77 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.77 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.77 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.77 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.77 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.77 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.77 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | TDP2 | O95551 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | CASP3 | P42574 | 2/20 | 1.00 |
| ▸ | RAD52 | P43351 | 2/20 | 1.00 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 1.00 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 1.00 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glaucine SCHEMBL11158386 | 1.00 | KDM4E (1.00) | KDM4ETDP2ALDH1A1MAPTCASP3 | |
| Glaucine SCHEMBL3040938 | 0.99 | HTR2A (1.00) | KDM4ETDP2ALDH1A1MAPTCASP3 | |
| Glaucine SCHEMBL146441 | 0.99 | HTR2A (1.00) | KDM4ETDP2ALDH1A1MAPTCASP3 | |
| Glaucine SCHEMBL29735463 | 0.99 | HTR2A (1.00) | KDM4ETDP2ALDH1A1MAPTCASP3 | |
| Glaucine SCHEMBL30213021 | 0.99 | HTR2A (1.00) | KDM4ETDP2ALDH1A1MAPTCASP3 | |
| Glaucine SCHEMBL11166124 | 0.97 | HTR2A (0.97) | KDM4ETDP2ALDH1A1MAPTCASP3 | |
| Glaucine SCHEMBL4312401 | 0.93 | HTR2A (0.88) | KDM4ETDP2ALDH1A1MAPTCASP3 | |
| Glaucine SCHEMBL7389697 | 0.92 | HTR2B (0.86) | KDM4ETDP2ALDH1A1MAPTCASP3 | |
| SCHEMBL4854015 | 0.90 | HTR7 (1.00) | KDM4ETDP2ALDH1A1MAPTCASP3 | |
| SCHEMBL30475142 | 0.90 | HTR7 (1.00) | KDM4ETDP2ALDH1A1MAPTCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309542-A | WITH A TRIMETHYLPHENYLAMMONIUM BASE | WARNER-LAMBERT COMPANY (US) | 1982-01-05 | — | — | US | disclosed |