Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 10/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11152277 | 0.87 | PDE3B (0.44) | PDE3BPDE3APDE4BGRIN1GRIN2B | |
| SCHEMBL11233887 | 0.86 | PDE3B (0.38) | PDE3BPDE3APDE4BGRIN1GRIN2B | |
| SCHEMBL11166310 | 0.83 | PDE3B (0.47) | PDE3BPDE3APDE4BGRIN1GRIN2B | |
| SCHEMBL11244916 | 0.81 | GRIN1 (0.61) | GRIN1GRIN2B | |
| Hydrochloric Acid SCHEMBL11353285 | 0.81 | PDE3B (0.45) | PDE3BPDE3APDE4BGRIN1GRIN2B | |
| SCHEMBL11154216 | 0.81 | ALDH1A1 (0.46) | PDE3BPDE3APDE4BGRIN1GRIN2B | |
| Hydrochloric Acid SCHEMBL11237795 | 0.81 | PDE3B (0.45) | PDE3BPDE3APDE4BGRIN1GRIN2B | |
| SCHEMBL11157645 | 0.80 | PDE3B (0.49) | PDE3BPDE3APDE4BGRIN1GRIN2B | |
| SCHEMBL11159832 | 0.80 | PDE3B (0.44) | PDE3BPDE3APDE4BGRIN1GRIN2B | |
| SCHEMBL11225213 | 0.78 | MTOR (0.38) | DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309537-A | Production of imidazo[4,5-b]pyridin-2-ones or thiones | STERLING DRUG INC. (US) | 1982-01-05 | — | — | US | disclosed |
| US-4297360-A | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |