Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | CD44 | P16070 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22461549 | 0.83 | HTR2A (0.35) | HTR2AHTR2CDRD2MAOBPNMT | |
| SCHEMBL7619310 | 0.77 | KDM1A (0.47) | MAOBPNMTKDM1AHDAC9 | |
| SCHEMBL5047677 | 0.77 | KDM1A (0.47) | MAOBPNMTKDM1AHDAC9 | |
| SCHEMBL10345420 | 0.77 | HTR2A (0.47) | HTR2AHTR2CDRD2MAOBPNMT | |
| SCHEMBL11696762 | 0.75 | KDM1A (0.54) | HTR2AHTR2CDRD2KDM1A | |
| SCHEMBL28831342 | 0.74 | KDM1A (0.41) | HTR2AHTR2CMAOBPNMTCD44 | |
| SCHEMBL10796154 | 0.73 | HTR2A (0.44) | HTR2AHTR2CDRD2MAOBPNMT | |
| SCHEMBL9058489 | 0.72 | HTR2A (0.62) | HTR2AHTR2CDRD2MAOBPNMT | |
| Phosphoric Acid SCHEMBL10603775 | 0.71 | HTR2A (0.42) | HTR2AHTR2CDRD2MAOBPNMT | |
| SCHEMBL11503433 | 0.71 | HTR2A (0.42) | HTR2AHTR2CDRD2MAOBPNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4382029-A | Process useful for preparing 7,8-acetamido, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE BECKMAN CORPORATION (US) | 1983-05-03 | — | — | US | disclosed |
| EP-0033632-B1 | 7,8-AMINO, HYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1983-03-30 | — | — | EP | disclosed |
| US-4327023-A | Intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1982-04-27 | — | — | US | disclosed |
| US-4284556-A | 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1981-08-18 | — | — | US | disclosed |
| EP-0033632-A2 | 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, process for their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1981-08-12 | — | — | EP | disclosed |