SCHEMBL11167652

SCHEMBL11167652

CCC(C#N)c1ccc(SC(F)(F)F)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
KDM4E B2RXH2 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
PTPRZ1 P23471 4/20 0.40
PTPN1 P18031 2/20 0.40
PDE2A O00408 5/20 0.36
LMNA P02545 1/20 0.35
POLB P06746 1/20 0.35
GAA P10253 1/20 0.35
ESR1 P03372 5/20 0.34
ESR2 Q92731 5/20 0.34
MEN1 O00255 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
KMT2A Q03164 1/20 0.34
AR P10275 2/20 0.33
SLC6A4 P31645 1/20 0.33
EPHX2 P34913 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11463216 0.87 ALDH1A1 (0.38) ALDH1A1KDM4ETDP1PTPRZ1PTPN1
SCHEMBL11151925 0.81 AR (0.33) AR
SCHEMBL29061982 0.77 FFAR1 (0.43) ALDH1A1PDE2AESR1ESR2MEN1
SCHEMBL954812 0.77 FFAR1 (0.43) ALDH1A1PDE2AESR1ESR2MEN1
SCHEMBL11157506 0.75 KDM4E (0.41) ALDH1A1KDM4ETDP1PTPRZ1PTPN1
SCHEMBL953000 0.74 KMT2A (0.46) ALDH1A1TDP1LMNAESR1ESR2
SCHEMBL29061981 0.74 KMT2A (0.46) ALDH1A1TDP1LMNAESR1ESR2
SCHEMBL15157652 0.74 SLC6A4 (0.61) ALDH1A1KDM4ETDP1PTPRZ1PTPN1
SCHEMBL954801 0.72 ALDH1A1 (0.41) ALDH1A1KDM4ETDP1LMNAGAA
SCHEMBL29061985 0.72 ALDH1A1 (0.41) ALDH1A1KDM4ETDP1LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4405639-A INSECTICIDES; PESTICIDES; MITICIDES; NEMATOCIDES; PARACITICIDES BAYER AKTIENGESELLSCHAFT (DE) 1983-09-20 US disclosed
US-4348323-A FLUORINE-CONTAINING BENZODIOXINE INSECTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1982-09-07 US disclosed
US-4284643-A Combating arthropods with novel fluorine-containing phenylacetic acid esters BAYER AKTIENGESELLSCHAFT (DE) 1981-08-18 US disclosed
US-4199595-A M-phenoxybenzyl and α-cyano-M-phenoxybenzyl esters of 2-haloalkyl (oxy-, thio-, sulfinyl-, or sulfonyl)phenylalkanoic acids AMERICAN CYANAMID COMPANY (US) 1980-04-22 US disclosed
EP-0008732-A2 Fluorine-containing esters of phenylacetic acids, process for their preparation and their use as insecticides and acaricides; intermediate products for their preparation BAYER AG (DE) 1980-03-19 EP disclosed
US-4178460-A INTERMEDIATES FOR INSECTICIDES AMERICAN CYANAMID CO. (US) 1979-12-11 US disclosed