Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | QPCT | Q16769 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11170700 | 0.91 | MAPT (0.57) | DRD2MAPTLMNAALOX15MAPK1 | |
| SCHEMBL11164429 | 0.91 | LMNA (0.59) | DRD2MAPTMEN1KMT2AUSP2 | |
| SCHEMBL11165829 | 0.91 | DRD2 (0.62) | DRD2MAPTUSP2SMN1; SMN2LMNA | |
| SCHEMBL11170034 | 0.89 | HTR2A (0.57) | DRD2MAPTMEN1KMT2AUSP2 | |
| SCHEMBL11169527 | 0.88 | DRD2 (0.58) | DRD2MAPTUSP2SMN1; SMN2LMNA | |
| SCHEMBL11169258 | 0.87 | DRD2 (0.57) | DRD2MAPTUSP2SMN1; SMN2LMNA | |
| SCHEMBL11167712 | 0.86 | MCHR1 (0.63) | DRD2MAPTUSP2SMN1; SMN2LMNA | |
| SCHEMBL11172796 | 0.85 | HTR2A (0.57) | DRD2MAPTMEN1KMT2AUSP2 | |
| SCHEMBL11165239 | 0.85 | HTR2A (0.58) | DRD2MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11166661 | 0.84 | DRD2 (0.67) | DRD2MEN1KMT2AHTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4413006-A | N-Aryl-N-phenoxy-alkyl-piperazine compounds useful in decreasing intracranial pressure | TANABE SEIYAKU CO., LTD. (JP) | 1983-11-01 | — | — | US | disclosed |
| EP-0034284-B1 | PIPERAZINE DERIVATIVE, PROCESSES FOR PREPARING THE SAME AND THERAPEUTIC COMPOSITIONS CONTAINING IT | Tanabe Seiyaku Co., Ltd. (JP) | 1983-10-05 | — | — | EP | disclosed |
| EP-0034284-A2 | Piperazine derivative, processes for preparing the same and therapeutic compositions containing it | Tanabe Seiyaku Co., Ltd. (JP) | 1981-08-26 | — | — | EP | disclosed |