Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11170034 | 0.91 | HTR2A (0.57) | HTR2AMAPTDRD2MEN1KMT2A | |
| SCHEMBL11164429 | 0.90 | LMNA (0.59) | HTR2AL3MBTL1MAPTDRD2MEN1 | |
| SCHEMBL11165829 | 0.90 | DRD2 (0.62) | HTR2AMAPTDRD2LMNAUSP2 | |
| SCHEMBL11165239 | 0.90 | HTR2A (0.58) | HTR2AMAPTDRD2MEN1KMT2A | |
| SCHEMBL11166971 | 0.89 | L3MBTL1 (0.54) | L3MBTL1MAPTTHRBDRD2MEN1 | |
| SCHEMBL11169527 | 0.87 | DRD2 (0.58) | MAPTDRD2LMNAUSP2ALDH1A1 | |
| SCHEMBL11169258 | 0.87 | DRD2 (0.57) | MAPTDRD2LMNAUSP2ALDH1A1 | |
| SCHEMBL11168269 | 0.86 | DRD2 (0.67) | HTR2AL3MBTL1MAPTDRD2MEN1 | |
| SCHEMBL11168272 | 0.85 | DRD2 (0.56) | HTR2AL3MBTL1MAPTDRD2MEN1 | |
| SCHEMBL11167712 | 0.85 | MCHR1 (0.63) | MAPTDRD2LMNAUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4413006-A | N-Aryl-N-phenoxy-alkyl-piperazine compounds useful in decreasing intracranial pressure | TANABE SEIYAKU CO., LTD. (JP) | 1983-11-01 | — | — | US | disclosed |
| EP-0034284-B1 | PIPERAZINE DERIVATIVE, PROCESSES FOR PREPARING THE SAME AND THERAPEUTIC COMPOSITIONS CONTAINING IT | Tanabe Seiyaku Co., Ltd. (JP) | 1983-10-05 | — | — | EP | disclosed |
| EP-0034284-A2 | Piperazine derivative, processes for preparing the same and therapeutic compositions containing it | Tanabe Seiyaku Co., Ltd. (JP) | 1981-08-26 | — | — | EP | disclosed |