Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11174233 | 0.81 | MAPT (0.50) | MAPTGAATP53MAPK1HSD17B10 | |
| SCHEMBL11169978 | 0.80 | MAPT (0.45) | MAPTGAATP53MAPK1HSD17B10 | |
| SCHEMBL11169204 | 0.79 | MAPT (0.34) | MAPTGAAMAPK1ALDH1A1KMT2A | |
| SCHEMBL11169745 | 0.77 | MAPT (0.43) | MAPTGAATP53MAPK1HSD17B10 | |
| SCHEMBL11170519 | 0.76 | MAPT (0.67) | MAPTGAATP53MAPK1HSD17B10 | |
| SCHEMBL29690676 | 0.75 | MAPT (0.44) | MAPTGAATP53MAPK1HSD17B10 | |
| SCHEMBL10601266 | 0.75 | MAPT (0.47) | MAPTGAATP53MAPK1HSD17B10 | |
| SCHEMBL1122539 | 0.74 | MAPT (0.53) | MAPTGAATP53MAPK1HSD17B10 | |
| SCHEMBL7850850 | 0.74 | GAA (0.43) | MAPTGAATP53MAPK1HSD17B10 | |
| SCHEMBL18684664 | 0.72 | MAPT (0.56) | MAPTGAATP53MAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4369325-A | ANTIPHLOGISTIC AND DIURETIC ACTIVITY | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 1983-01-18 | — | — | US | disclosed |
| US-4284642-A | DIURETICS, ANTIPHLOGISTICS | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 1981-08-18 | — | — | US | disclosed |