Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248759 | 0.75 | L3MBTL1 (0.44) | GAAKMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL13745534 | 0.75 | GAA (0.44) | GAAMAPTTP53MAPK1HSD17B10 | |
| SCHEMBL23520609 | 0.75 | KMT2A (0.37) | MAPTKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL1122539 | 0.74 | MAPT (0.53) | GAAMAPTTP53MAPK1HSD17B10 | |
| SCHEMBL11174233 | 0.74 | MAPT (0.50) | GAAMAPTTP53MAPK1HSD17B10 | |
| SCHEMBL11171569 | 0.74 | MAPT (0.46) | GAAMAPTTP53MAPK1HSD17B10 | |
| SCHEMBL5608579 | 0.73 | HTT (0.51) | GAAMAPTHSD17B10CYP3A4NLRP3 | |
| SCHEMBL11169978 | 0.72 | MAPT (0.45) | GAAMAPTTP53MAPK1HSD17B10 | |
| SCHEMBL27895396 | 0.72 | TSHR (0.50) | GAAHSD17B10NLRP3ALDH1A1HPGD | |
| SCHEMBL11170519 | 0.72 | MAPT (0.67) | GAAMAPTTP53MAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891350-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-01-17 | — | — | EP | disclosed |
| EP-0891350-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| US-5859012-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1997036889-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |